H
Hsien Yang Lee
Researcher at University of California, San Francisco
Publications - 3
Citations - 444
Hsien Yang Lee is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: PNKD & Cortical spreading depression. The author has an hindex of 3, co-authored 3 publications receiving 388 citations.
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Journal ArticleDOI
Mutations in the Gene PRRT2 Cause Paroxysmal Kinesigenic Dyskinesia with Infantile Convulsions
Hsien Yang Lee,Yong Huang,Yong Huang,Nadine Bruneau,Patrice Roll,Elisha D.O. Roberson,Mark Hermann,Emily Quinn,Emily Quinn,James W. Maas,Robert H. Edwards,Tetsuo Ashizawa,Betül Baykan,Kailash P. Bhatia,Susan B. Bressman,Michiko K. Bruno,Michiko K. Bruno,Ewout R. Brunt,Roberto Caraballo,Bernard Echenne,Natalio Fejerman,Steve Frucht,Christina A. Gurnett,Edouard Hirsch,Henry Houlden,Joseph Jankovic,Wei Ling Lee,David A. Lynch,Shehla Mohammed,Ulrich Müller,Mark Nespeca,David Renner,Jacques Rochette,Gabrielle Rudolf,Shinji Saiki,Bing-Wen Soong,Bing-Wen Soong,Kathryn J. Swoboda,Sam Tucker,Nicholas W. Wood,Michael G. Hanna,Anne M. Bowcock,Pierre Szepetowski,Ying-Hui Fu,Louis J. Ptáček,Louis J. Ptáček +45 more
TL;DR: Four truncating mutations involving the gene PRRT2 in the vast majority of well-characterized families with PKD/IC are identified, leading ultimately to neuronal hyperexcitability that manifests in vivo as PKd/IC.
Journal ArticleDOI
Casein Kinase Iδ Mutations in Familial Migraine and Advanced Sleep Phase
Kevin C. Brennan,Emily A. Bates,Emily A. Bates,Robert E. Shapiro,Jekaterina Zyuzin,William C. Hallows,Yong Huang,Hsien Yang Lee,Christopher R. Jones,Ying-Hui Fu,Andrew Charles,Louis J. Ptáček +11 more
TL;DR: The suggestive segregation of the casein kinase mutations in migraine patients and the ability of the same mutations to produce migraine-like phenomena in mice together make a strong case that casein Kinase mutations can contribute to migraine, adding another gene to the small list associated with this debilitating headache syndrome.
Journal ArticleDOI
Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis
Yiguo Shen,Woo Ping Ge,Yulong Li,Arisa Hirano,Hsien Yang Lee,Astrid Rohlmann,Markus Missler,Richard W. Tsien,Lily Yeh Jan,Ying-Hui Fu,Louis J. Ptáček +10 more
TL;DR: PNKD is a novel synaptic protein with a regulatory role in neurotransmitter release that interacts with synaptic active zone proteins Rab3-interacting molecule (RIM)1 and RIM2, localizes to synapses, and modulates neurotransmitterRelease.