Hua Chen

TL;DR: A likelihood method for detecting selective sweeps that involves jointly modeling the multilocus allele frequency differentiation between two populations is presented, which is much more robust to ascertainment bias in SNP discovery than methods based on the allele frequency spectrum.

TL;DR: Analysis of genome-wide sequence variations in Tibetans indicates strong signals of selective sweep in two hypoxia-related genes, EPAS1 and EGLN1, and suggests that during the long-term occupation of high-altitude areas, the functional sequence variations for acquiring biological adaptation to high-Altitude Hypoxia have been enriched in Tibetan populations.

TL;DR: It is suggested that rigorous quarantine and control measures should be kept before early March in Beijing, Shanghai, Guangzhou and Shenzhen, and before late March in Hubei, to prevent the spread of COVID-19.

TL;DR: It is found that EDAR370A is associated with an increased number of active eccrine glands in the Han Chinese, and this interdisciplinary approach yields unique insight into the generation of adaptive variation among modern humans.

TL;DR: The genetic data indicate that Tibetans have been adapted to a high altitude environment since initial colonization of the Tibetan Plateau in the early Upper Paleolithic, before the last glacial maximum, followed by a rapid population expansion that coincided with the establishment of farming and yak pastoralism on the PlateauIn the early Neolithic.