H
Huaming Chen
Researcher at Salk Institute for Biological Studies
Publications - 51
Citations - 19304
Huaming Chen is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: DNA methylation & Epigenomics. The author has an hindex of 27, co-authored 45 publications receiving 17366 citations. Previous affiliations of Huaming Chen include University of Pennsylvania & Howard Hughes Medical Institute.
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Journal ArticleDOI
Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana
Jose M. Alonso,Anna Stepanova,Thomas J. Leisse,Christopher J. Kim,Huaming Chen,Paul Shinn,Denise K. Stevenson,Justin Zimmerman,Pascual Barajas,Rosa Cheuk,Carmelita Gadrinab,Collen Heller,Albert Jeske,Eric Koesema,Cristina C. Meyers,Holly Parker,Lance Prednis,Yasser Ansari,Nathan Choy,Hashim Deen,Michael Geralt,Nisha Hazari,Emily Hom,Meagan Karnes,Celene Mulholland,Ral Ndubaku,Ian Thomas Schmidt,Plinio Guzmán,Laura Aguilar-Henonin,Markus Schmid,Detlef Weigel,David E. Carter,Trudy Marchand,Eddy Risseeuw,Debra Brogden,Albana Zeko,William L. Crosby,Charles C. Berry,Joseph R. Ecker +38 more
TL;DR: Genome-wide analysis of the distribution of integration events revealed the existence of a large integration site bias at both the chromosome and gene levels, and insertion mutations were identified in genes that are regulated in response to the plant hormone ethylene.
Journal ArticleDOI
HIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots
Astrid R. W Schroder,Paul Shinn,Huaming Chen,Charles C. Berry,Joseph R. Ecker,Frederic D. Bushman +5 more
TL;DR: Global analysis of cellular transcription indicated that active genes were preferential integration targets, particularly genes that were activated in cells after infection by HIV-1, and this data suggests how selective targeting promotes aggressive HIV replication.
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Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis.
Xiaoyu Zhang,Junshi Yazaki,Ambika Sundaresan,Shawn J. Cokus,Simon W. L. Chan,Huaming Chen,Ian R. Henderson,Paul Shinn,Matteo Pellegrini,Steve E. Jacobsen,Joseph R. Ecker +10 more
TL;DR: This is the first comprehensive DNA methylation map of an entire genome, at 35 base pair resolution, using the flowering plant Arabidopsis thaliana as a model and finds that pericentromeric heterochromatin, repetitive sequences, and regions producing small interfering RNAs are heavily methylated.
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Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues
Xinmin Zhang,Duncan T. Odom,Seung Hoi Koo,Michael D. Conkright,Gianluca Canettieri,Jennifer L. Best,Huaming Chen,Richard G. Jenner,Elizabeth Herbolsheimer,Elisabeth Jacobsen,Shilpa Kadam,Joseph R. Ecker,Beverly M. Emerson,John B. Hogenesch,Terry G. Unterman,Richard A. Young,Marc Montminy +16 more
TL;DR: The results indicate that CREB phosphorylation alone is not a reliable predictor of target gene activation and that additional CREB regulatory partners are required for recruitment of the transcriptional apparatus to the promoter.
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Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences.
Richard S. Mitchell,Brett Beitzel,Astrid R. W Schroder,Paul Shinn,Huaming Chen,Charles C. Berry,Joseph R. Ecker,Frederic D. Bushman +7 more
TL;DR: Each of the three retroviruses studied showed unique integration site preferences, suggesting that virus-specific binding of integration complexes to chromatin features likely guides site selection.