H
Huaming Chen
Researcher at Salk Institute for Biological Studies
Publications - 51
Citations - 19304
Huaming Chen is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: DNA methylation & Epigenomics. The author has an hindex of 27, co-authored 45 publications receiving 17366 citations. Previous affiliations of Huaming Chen include University of Pennsylvania & Howard Hughes Medical Institute.
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Journal ArticleDOI
Integrated multi-omics framework of the plant response to jasmonic acid
Mark Zander,Mathew G. Lewsey,Mathew G. Lewsey,Natalie M. Clark,Lingling Yin,Lingling Yin,Anna Bartlett,J. Paola Saldierna Guzmán,J. Paola Saldierna Guzmán,Elizabeth Hann,Elizabeth Hann,Amber E. Langford,Bruce Jow,Aaron Wise,Joseph R. Nery,Huaming Chen,Ziv Bar-Joseph,Justin W. Walley,Roberto Solano,Joseph R. Ecker +19 more
TL;DR: This work investigated the signalling pathway of the hormone jasmonic acid (JA), which controls a plethora of critically important processes in plants and is orchestrated by the transcription factor MYC2 and its closest relatives in Arabidopsis thaliana, and generated an integrated framework of the response to JA.
Journal ArticleDOI
Exploring the transcriptional landscape of plant circadian rhythms using genome tiling arrays
Samuel P. Hazen,Samuel P. Hazen,Felix Naef,Tom Quisel,Joshua M. Gendron,Huaming Chen,Joseph R. Ecker,Justin O. Borevitz,Steve A. Kay +8 more
TL;DR: This study revealed widespread circadian clock regulation of the Arabidopsis genome extending well beyond the protein coding transcripts measured to date, which suggests a greater level of structural and temporal dynamics than previously known.
Journal ArticleDOI
The complex architecture and epigenomic impact of plant T-DNA insertions
Florian Jupe,Angeline Rivkin,Todd P. Michael,Mark Zander,S. Timothy Motley,Justin P. Sandoval,R. Keith Slotkin,Huaming Chen,Rosa Castanon,Joseph R. Nery,Joseph R. Ecker +10 more
TL;DR: New insights are provided into the structural impact of inserting foreign fragments into plant genomes and the utility of state-of-the-art long-range sequencing technologies to rapidly identify unanticipated genomic changes are demonstrated.
Journal ArticleDOI
DNA methylation atlas of the mouse brain at single-cell resolution.
Hanqing Liu,Hanqing Liu,Jingtian Zhou,Jingtian Zhou,Wei Tian,Chongyuan Luo,Chongyuan Luo,Anna Bartlett,Andrew Aldridge,Jacinta Lucero,Julia K. Osteen,Joseph R. Nery,Huaming Chen,Angeline Rivkin,Rosa Castanon,Ben Clock,Yang Eric Li,Xiaomeng Hou,Olivier Poirion,Sebastian Preissl,Antonio Pinto-Duarte,Carolyn O’Connor,Lara Boggeman,Conor Fitzpatrick,Michael Nunn,Eran A. Mukamel,Zhuzhu Zhang,Edward M. Callaway,Bing Ren,Jesse R. Dixon,M. Margarita Behrens,Joseph R. Ecker +31 more
TL;DR: In this article, a comprehensive assessment of the epigenomes of mouse brain cell types by applying single-nucleus DNA methylation sequencing was carried out to profile 103,982 nuclei (including 95,815 neurons and 8,167 non-neuronal cells) from 45 regions of the mouse cortex, hippocampus, striatum, pallidum and olfactory areas.
Posted ContentDOI
DNA Methylation Atlas of the Mouse Brain at Single-Cell Resolution
Hanqing Liu,Hanqing Liu,Jingtian Zhou,Jingtian Zhou,Wei Tian,Chongyuan Luo,Chongyuan Luo,Anna Bartlett,Andrew Aldridge,Jacinta Lucero,Julia K. Osteen,Joseph R. Nery,Huaming Chen,Angeline Rivkin,Rosa Castanon,Ben Clock,Yang Eric Li,Xiaomeng Hou,Olivier Poirion,Sebastian Preissl,Carolyn O’Connor,Lara Boggeman,Conor Fitzpatrick,Michael Nunn,Eran A. Mukamel,Zhuzhu Zhang,Edward M. Callaway,Bing Ren,Bing Ren,Jesse R. Dixon,M. Margarita Behrens,Joseph R. Ecker +31 more
TL;DR: By combining multi-omic datasets (DNA methylation, chromatin contacts, and open chromatin) from single nuclei and annotating the regulatory genome of hundreds of cell types in the mouse brain, the DNA methylation atlas establishes the epigenetic basis for neuronal diversity and spatial organization throughout the Mouse brain.