H
Huayun Hou
Researcher at University of Toronto
Publications - 21
Citations - 611
Huayun Hou is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 6, co-authored 14 publications receiving 404 citations. Previous affiliations of Huayun Hou include Peking University & Hospital for Sick Children.
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Journal ArticleDOI
Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders.
Liis Uusküla-Reimand,Huayun Hou,Payman Samavarchi-Tehrani,Matteo Vietri Rudan,Minggao Liang,Alejandra Medina-Rivera,Hisham Mohammed,Hisham Mohammed,Dominic Schmidt,Petra C. Schwalie,Edwin J. Young,Jüri Reimand,Jüri Reimand,Suzana Hadjur,Anne-Claude Gingras,Anne-Claude Gingras,Michael D. Wilson +16 more
TL;DR: TOP2B is positioned to solve topological problems at diverse cis-regulatory elements and its occupancy is a highly ordered and prevalent feature of CTCF/cohesin binding sites that flank TADs.
Journal ArticleDOI
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains
Jean-Philippe Lambert,Sarah Picaud,Takao Fujisawa,Huayun Hou,Pavel Savitsky,Liis Uusküla-Reimand,Gagan D. Gupta,Hala Abdouni,Zhen-Yuan Lin,Monika Tucholska,James D.R. Knight,Beatriz Gonzalez-Badillo,Nicole St-Denis,J.A. Newman,Manuel Stucki,Laurence Pelletier,Laurence Pelletier,Nuno Bandeira,Nuno Bandeira,Michael D. Wilson,Panagis Filippakopoulos,Panagis Filippakopoulos,Anne-Claude Gingras,Anne-Claude Gingras +23 more
TL;DR: An unexpected increase in several interactions following JQ1 treatment that define negative functions for BRD3 in the regulation of rRNA synthesis and potentially RNAPII-dependent gene expression that result in decreased cell proliferation are identified.
Journal ArticleDOI
Correction of a splicing defect in a mouse model of congenital muscular dystrophy type 1A using a homology-directed-repair-independent mechanism
Dwi U. Kemaladewi,Eleonora Maino,Elzbieta Hyatt,Huayun Hou,Maylynn Ding,Kara M Place,Xinyi Zhu,Prabhpreet S Bassi,Zahra Baghestani,Amit G. Deshwar,Daniele Merico,Daniele Merico,Hui Yuan Xiong,Brendan J. Frey,Michael D. Wilson,Evgueni A. Ivakine,Ronald D. Cohn +16 more
TL;DR: This work focuses on congenital muscular dystrophy type 1A, which is characterized by severe muscle wasting and paralysis, and describes a strategy using nonhomologous end-joining (NHEJ) to correct a pathogenic splice-site mutation.
Journal ArticleDOI
Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells
Najeeb U. Siddiqui,Xiao Li,Hua Luo,Angelo Karaiskakis,Huayun Hou,Huayun Hou,Thomas Kislinger,J. Timothy Westwood,Quaid Morris,Howard D. Lipshitz +9 more
TL;DR: It is reported that genome-wide analyses of the MZT for primordial germ cells (PGCs), the progenitors of the germ-line stem cells, are reported for the first time, suggesting that Smaug and AU-rich element binding proteins function independently to control transcript elimination.
Journal ArticleDOI
Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma
Wen-Chi Yin,Thevagi Satkunendran,Rong Mo,Sorana Morrissy,Xiaoyun Zhang,Eunice Shiao Huang,Liis Uusküla-Reimand,Huayun Hou,Joe Eun Son,Weifan Liu,Yulu C. Liu,Jianing Zhang,Jessica Parker,Xin Wang,Hamza Farooq,Hayden J. Selvadurai,Xin Chen,Elly Sau-Wai Ngan,Steven Y. Cheng,Peter B. Dirks,Stephane Angers,Michael D. Wilson,Michael D. Taylor,Chi-chung Hui +23 more
TL;DR: This work establishes the dual role of SUFU inSHH MB and provides mechanistic insights into transcriptional regulation underlying Gli2-mediated SHH MB tumorigenesis and identifies Atoh1 as a target and molecular accomplice of Gli 2 that activates core SHHMB signature genes in a synergistic manner.