H
Huey Hsuan Chang
Researcher at French Institute of Health and Medical Research
Publications - 4
Citations - 1854
Huey Hsuan Chang is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Innate immune system & Toll-like receptor. The author has an hindex of 4, co-authored 4 publications receiving 1782 citations. Previous affiliations of Huey Hsuan Chang include Pasteur Institute.
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Journal ArticleDOI
Pyogenic Bacterial Infections in Humans with MyD88 Deficiency
Horst von Bernuth,Capucine Picard,Capucine Picard,Zhongbo Jin,Rungnapa Pankla,Rungnapa Pankla,Hui Xiao,Cheng-Lung Ku,Cheng-Lung Ku,Maya Chrabieh,Maya Chrabieh,Imen Ben Mustapha,Imen Ben Mustapha,Imen Ben Mustapha,Pegah Ghandil,Pegah Ghandil,Yildiz Camcioglu,Júlia Vasconcelos,Nicolas Sirvent,Margarida Guedes,Artur Bonito Vitor,María José Herrero-Mata,Juan I. Aróstegui,Carlos Rodrigo,Laia Alsina,Estibaliz Ruiz-Ortiz,Manel Juan,Claudia Fortuny,Jordi Yagüe,Jordi Anton,Mariona Pascal,Huey Hsuan Chang,Lucile Janniere,Lucile Janniere,Yoann Rose,Yoann Rose,Ben Zion Garty,Helen Chapel,Andrew C. Issekutz,László Maródi,Carlos Rodríguez-Gallego,Jacques Banchereau,Laurent Abel,Laurent Abel,Xiaoxia Li,Damien Chaussabel,Anne Puel,Anne Puel,Jean-Laurent Casanova,Jean-Laurent Casanova +49 more
TL;DR: Nine children with autosomal recessive MyD88 deficiency suffered from life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, but these patients were otherwise healthy, with normal resistance to other microbes.
Journal ArticleDOI
Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity
Cheng-Lung Ku,Horst von Bernuth,Horst von Bernuth,Capucine Picard,Shen-Ying Zhang,Huey Hsuan Chang,Kun Yang,Maya Chrabieh,Andrew C. Issekutz,Coleen K. Cunningham,John I. Gallin,Steven M. Holland,Chaim M. Roifman,Stephan Ehl,Joanne Smart,Mimi L.K. Tang,Franck J. Barrat,Ofer Levy,Douglas R. McDonald,Noorbibi K. Day-Good,Richard L. Miller,Hidetoshi Takada,Toshiro Hara,Sami Al-Hajjar,Abdulaziz Al-Ghonaium,David P. Speert,Damien Sanlaville,Xiaoxia Li,Frederic Geissmann,Eric Vivier,László Maródi,Ben Zion Garty,Helen Chapel,Carlos Rodríguez-Gallego,Xavier Bossuyt,Laurent Abel,Anne Puel,Jean-Laurent Casanova +37 more
TL;DR: The IRAK-4–dependent TLRs and IL-1Rs are therefore vital for childhood immunity to pyogenic bacteria, particularly Streptococcus pneumoniae, and appear to play a redundant role in protective immunity to most infections.
Journal ArticleDOI
IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease
Cheng-Lung Ku,Capucine Picard,Melinda Erdos,Axel Jeurissen,Jacinta Bustamante,Anne Puel,Horst von Bernuth,Orchidée Filipe-Santos,Huey Hsuan Chang,Tatiana Lawrence,Marc Raes,László Maródi,Xavier Bossuyt,Jean-Laurent Casanova +13 more
TL;DR: Otherwise healthy children with recurrent IPD should be explored for underlying primary immunodeficiencies affecting the IRAK4-dependent and NEMO-dependent signalling pathways.
Journal ArticleDOI
NEMO is a key component of NF-κB- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus
Magali Audry,Michael J. Ciancanelli,Kun Yang,Kun Yang,Aurélie Cobat,Huey Hsuan Chang,Vanessa Sancho-Shimizu,Lazaro Lorenzo,Tim Niehues,Janine Reichenbach,Xiao Xia Li,Alain Israël,Laurent Abel,Laurent Abel,Jean-Laurent Casanova,Shen-Ying Zhang,Shen-Ying Zhang,Shen-Ying Zhang,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Anne Puel +21 more
TL;DR: Herpes simplex encephalitis may occur in patients carrying NF-κB essential modulator mutations, due to the impairment of NF-β- and interferon regulatory factor 3-dependent-TLR3-mediated antiviral IFN production.