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Xavier Bossuyt
Researcher at Katholieke Universiteit Leuven
Publications - 339
Citations - 11040
Xavier Bossuyt is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 46, co-authored 295 publications receiving 9332 citations. Previous affiliations of Xavier Bossuyt include Université catholique de Louvain & Maastricht University.
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Journal ArticleDOI
A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial)
Pierre Quartier,Florence Allantaz,Rolando Cimaz,Pascal Pillet,Claude Messiaen,Christophe Bardin,Xavier Bossuyt,Anne Boutten,Jacques Bienvenu,Agnès Duquesne,O. Richer,Damien Chaussabel,Agnes Mogenet,Jacques Banchereau,Jean-Marc Tréluyer,Paul Landais,Virginia Pascual +16 more
TL;DR: Anakinra treatment is effective in SJIA, at least in the short term, and is associated with normalisation of blood gene expression profiles in clinical responders and induces a de novo IFN signature.
Journal ArticleDOI
International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies
Nancy Agmon-Levin,Nancy Agmon-Levin,Jan Damoiseaux,Cornelis Kallenberg,Ulrich Sack,Torsten Witte,Manfred Herold,Manfred Herold,Xavier Bossuyt,L. Musset,Ricard Cervera,Aresio Plaza-Lopez,Carlos Tadeu dos Santos Dias,Maria José Rego Sousa,Antonella Radice,Catharina Eriksson,Olof Hultgren,Markku Viander,Munther A. Khamashta,Stephan Regenass,Luis Eduardo Coelho Andrade,Allan Wiik,Angela Tincani,Johan Rönnelid,Daniel Bloch,Marvin J. Fritzler,Edward K. L. Chan,I. Garcia-De La Torre,Konstantin N. Konstantinov,Robert Lahita,Merlin R. Wilson,Olli Vainio,Nicole Fabien,Renato Alberto Sinico,Pier Luigi Meroni,Yehuda Shoenfeld,Yehuda Shoenfeld +36 more
TL;DR: Recommendations for the assessment and interpretation of ANA and associated antibodies were formulated and the roles of IIFA as a reference method, and the importance of defining nuclear and cytoplasmic staining were emphasised, while the need to incorporate alternative automated methods was acknowledged.
Journal ArticleDOI
Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity
Cheng-Lung Ku,Horst von Bernuth,Horst von Bernuth,Capucine Picard,Shen-Ying Zhang,Huey Hsuan Chang,Kun Yang,Maya Chrabieh,Andrew C. Issekutz,Coleen K. Cunningham,John I. Gallin,Steven M. Holland,Chaim M. Roifman,Stephan Ehl,Joanne Smart,Mimi L.K. Tang,Franck J. Barrat,Ofer Levy,Douglas R. McDonald,Noorbibi K. Day-Good,Richard L. Miller,Hidetoshi Takada,Toshiro Hara,Sami Al-Hajjar,Abdulaziz Al-Ghonaium,David P. Speert,Damien Sanlaville,Xiaoxia Li,Frederic Geissmann,Eric Vivier,László Maródi,Ben Zion Garty,Helen Chapel,Carlos Rodríguez-Gallego,Xavier Bossuyt,Laurent Abel,Anne Puel,Jean-Laurent Casanova +37 more
TL;DR: The IRAK-4–dependent TLRs and IL-1Rs are therefore vital for childhood immunity to pyogenic bacteria, particularly Streptococcus pneumoniae, and appear to play a redundant role in protective immunity to most infections.
Journal ArticleDOI
Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency
Capucine Picard,Capucine Picard,Horst von Bernuth,Horst von Bernuth,Horst von Bernuth,Pegah Ghandil,Pegah Ghandil,Pegah Ghandil,Maya Chrabieh,Maya Chrabieh,Ofer Levy,Peter D. Arkwright,Douglas R. McDonald,Raif S. Geha,Hidetoshi Takada,Jens C. Krause,C. Buddy Creech,Cheng-Lung Ku,Cheng-Lung Ku,Stephan Ehl,László Maródi,Saleh Al-Muhsen,Saleh Al-Muhsen,Sami Al-Hajjar,Sami Al-Hajjar,Abdulaziz Al-Ghonaium,Abdulaziz Al-Ghonaium,Noorbibi K. Day-Good,Steven M. Holland,John I. Gallin,Helen Chapel,David P. Speert,Carlos Rodríguez-Gallego,Elena Colino,Ben Zion Garty,Chaim M. Roifman,Toshiro Hara,Hideto Yoshikawa,Shigeaki Nonoyama,Joseph B. Domachowske,Andrew C. Issekutz,Mimi L.K. Tang,Joanne Smart,Simona Eva Zitnik,Cyrille Hoarau,Dinakantha S. Kumararatne,Adrian J. Thrasher,E. Graham Davies,Claire Bethune,Nicolas Sirvent,Dominique De Ricaud,Yildiz Camcioglu,Júlia Vasconcelos,Margarida Guedes,Artur Bonito Vitor,Carlos Rodrigo,Francisco Almazán,Maria Méndez,Juan I. Aróstegui,Laia Alsina,Claudia Fortuny,Janine Reichenbach,James W. Verbsky,Xavier Bossuyt,Rainer Döffinger,Laurent Abel,Laurent Abel,Anne Puel,Anne Puel,Jean-Laurent Casanova +69 more
TL;DR: IRAK-4 and MyD88 deficiencies predispose patients to recurrent life-threatening bacterial diseases, such as invasive pneumococcal disease in particular, in infancy and early childhood, with weak signs of inflammation.
Journal ArticleDOI
Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease
Marc Peeters,Sofie Joossens,Severine Vermeire,Robert Vlietinck,Xavier Bossuyt,Paul Rutgeerts +5 more
TL;DR: Diagnostic value of anti- Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease is found to be low.