Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons.
Hui Ling Wang,Shiliang Zhang,Jia Qi,Huikun Wang,Roger Cachope,Carlos A. Mejias-Aponte,Jorge A. Gomez,Gabriel E Mateo-Semidey,Gerard M.J. Beaudoin,Carlos A. Paladini,Joseph F. Cheer,Marisela Morales +11 more
Reads0
Chats0
TLDR
A path-specific input from DR serotonergic neurons to VTA that promotes reward by the release of glutamate and activation of mesoaccumbens dopamine neurons is suggested.About:
This article is published in Cell Reports.The article was published on 2019-01-29 and is currently open access. It has received 102 citations till now. The article focuses on the topics: Ventral tegmental area & Dopamine.read more
Citations
More filters
Journal ArticleDOI
Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei.
Jing Ren,Alina Isakova,Drew Friedmann,Jiawei Zeng,Sophie M. Grutzner,Albert Pun,Grace Zhao,Sai Saroja Kolluru,Ruiyu Wang,Rui Lin,Pengcheng Li,Anan Li,Jennifer L. Raymond,Qingming Luo,Minmin Luo,Stephen R. Quake,Liqun Luo +16 more
TL;DR: Reconstruction of 50 individual DR serotonin neurons revealed diverse and segregated axonal projection patterns at the single-cell level, providing a molecular foundation of the heterogenous serotonin neuronal phenotypes.
Journal ArticleDOI
The hypocretin (orexin) system: from a neural circuitry perspective
Shi-Bin Li,Luis de Lecea +1 more
TL;DR: This review focuses on the function of neural pathways from hypocretin neurons to target brain regions, and the development of pharmaceutical compounds targeting hypocrretin signaling.
Journal ArticleDOI
Revisiting the role of neurotransmitters in epilepsy: An updated review
TL;DR: Critical findings of the current literature about the role of neurotransmitters in epilepsy are provided and the emerging implication of mutations in neurotransmitter-mediated receptors and ion channels are discussed.
Journal ArticleDOI
Plasticity of the Reward Circuitry After Early-Life Adversity: Mechanisms and Significance.
Matthew T. Birnie,Cassandra L. Kooiker,Annabel K. Short,Jessica L. Bolton,Yuncai Chen,Tallie Z. Baram +5 more
TL;DR: Focusing on amygdala nuclei and their projections, evidence is provided suggesting that aberrant CRF expression and function may underlie augmented connectivity of the nucleus accumbens with fear/anxiety regions, disrupting the function of this critical locus of pleasure and reward.
Journal ArticleDOI
Phasic Activation of Dorsal Raphe Serotonergic Neurons Increases Pupil Size
TL;DR: It is shown that phasic 5-HT neuron stimulation causes transient PS changes and is observed that the effect of 5- HT on PS depended on the level of environmental uncertainty, consistent with the idea that5-HT could report a surprise signal.
References
More filters
Journal ArticleDOI
Dopamine, learning and motivation
TL;DR: Dopamine release in the nucleus accumbens has been linked to the efficacy of these unconditioned rewards, but dopamine release in a broader range of structures is implicated in the 'stamping-in' of memory that attaches motivational importance to otherwise neutral environmental stimuli.
Journal ArticleDOI
The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
Book
The Fine Structure of the Nervous System: Neurons and Their Supporting Cells
TL;DR: The best ebooks about Fine Structure Of the Nervous System Neurons And Their Supporting Cells that you can get for free here by download this Fine structure of the nervous systemNeurons and their free ebooks.
Journal ArticleDOI
The spectrum of behaviors influenced by serotonin
TL;DR: The diverse array of behavioral effects of serotonin form the basis for understanding its potential role as an etiological marker in psychiatric disorders and for the successful pharmacologic intervention of drugs regulating serotonin neurotransmission in behavior.
Journal ArticleDOI
Projections from the rat prefrontal cortex to the ventral tegmental area: target specificity in the synaptic associations with mesoaccumbens and mesocortical neurons.
David B. Carr,Susan R. Sesack +1 more
TL;DR: The unexpected finding of selective PFC synaptic input to GABA- containing mesoaccumbens neurons and DA-containing mesocortical neurons suggests novel mechanisms through which the PFC can influence the activity of ascending DA and GABA projections.