Jorge A. Gomez

TL;DR: A path-specific input from DR serotonergic neurons to VTA that promotes reward by the release of glutamate and activation of mesoaccumbens dopamine neurons is suggested.

TL;DR: It is demonstrated that the rapid elevation in dopamine levels and motor activity elicited by cocaine involves α1 receptor activation within the ventral midbrain, and the mechanism underlying the critical role of α1 adrenergic receptors in the regulation of dopamine neurotransmission and behavior is demonstrated.

TL;DR: The authors show that astrocytes in the VTA selectively facilitate excitation of VTA GABAergic neurons to inhibit dopamine neurons and drive avoidance behavior via GLT-1, which dynamically control glutamate availability at specific active synapses through the glutamate transporter, GLT -1.

TL;DR: The utility of the baboon model for testing and optimizing the efficacy and safety of stem cell‐based therapeutic approaches for the treatment of Parkinson's disease is demonstrated.

TL;DR: It is reported that VTA astrocytes tune glutamatergic signaling selectively on local inhibitory neurons to drive a functional circuit for learned avoidance.