Hwee Cheng Tan

TL;DR: These findings demonstrate a distinctive viral RNA–host protein interaction to evade the innate immune response for increased epidemiological fitness.

TL;DR: Using a dengue virus serotype 2 (DENV-2) vaccine strain (PDK53), it is shown that infection creates an endogenous source of cytosolic DNA in infected cells through the release of mitochondrial DNA to drive the production of cGAMP by cGAS.

TL;DR: In this article, the authors performed serological and T-cell analysis in a cohort of 20 healthcare workers after receiving the first dose of the Pfizer/BioNTech BNT162b2 vaccine and found Spike-specific T-cells and binding antibodies were detectable 10 days after the vaccine.

TL;DR: Using convalescent sera from dengue patients, it is observed that neutralization of the homologous serotypes occurred despite FcγR-mediated uptake, and it is demonstrated that this inhibition occurred through the formation of viral aggregates by antibodies in a concentration-dependent manner.

TL;DR: In this article, the authors employed a non-immunodominant, but functionally relevant, epitope in domain III of the E protein and engineered an antibody directed to it, which exhibits high affinity binding to, and broadly neutralizes, multiple genotypes within all four serotypes.