Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness
Gayathri Manokaran,Esteban Finol,Esteban Finol,Chunling Wang,Jayantha Gunaratne,Jayantha Gunaratne,Justin Bahl,Eugenia Z. Ong,Hwee Cheng Tan,October M. Sessions,Alex M. Ward,Duane J. Gubler,Eva Harris,Mariano A. Garcia-Blanco,Mariano A. Garcia-Blanco,Mariano A. Garcia-Blanco,Eng Eong Ooi,Eng Eong Ooi +17 more
TLDR
These findings demonstrate a distinctive viral RNA–host protein interaction to evade the innate immune response for increased epidemiological fitness.Abstract:
The global spread of dengue virus (DENV) infections has increased viral genetic diversity, some of which appears associated with greater epidemic potential. The mechanisms governing viral fitness in epidemiological settings, however, remain poorly defined. We identified a determinant of fitness in a foreign dominant (PR-2B) DENV serotype 2 (DENV-2) clade, which emerged during the 1994 epidemic in Puerto Rico and replaced an endemic (PR-1) DENV-2 clade. The PR-2B DENV-2 produced increased levels of subgenomic flavivirus RNA (sfRNA) relative to genomic RNA during replication. PR-2B sfRNA showed sequence-dependent binding to and prevention of tripartite motif 25 (TRIM25) deubiquitylation, which is critical for sustained and amplified retinoic acid–inducible gene 1 (RIG-I)–induced type I interferon expression. Our findings demonstrate a distinctive viral RNA–host protein interaction to evade the innate immune response for increased epidemiological fitness.read more
Citations
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A brave new world of RNA-binding proteins
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Jan Rehwinkel,Michaela U. Gack +1 more
TL;DR: How members of the RLR family are regulated is explained and the importance of the RLRs in viral infection, autoimmunity and cancer is reflected on.
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Zika virus: History, emergence, biology, and prospects for control.
Scott C. Weaver,Federico Costa,Mariano A. Garcia-Blanco,Albert I. Ko,Guilherme S. Ribeiro,George R. Saade,Pei Yong Shi,Nikos Vasilakis +7 more
TL;DR: Zika virus (ZIKV), a previously obscure flavivirus closely related to dengue, West Nile, Japanese encephalitis and yellow fever viruses, has emerged explosively since 2007 to cause a series of epidemics in Micronesia, the South Pacific, and most recently the Americas as discussed by the authors.
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Viral evasion of intracellular DNA and RNA sensing
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TL;DR: The strategies that viruses use to escape immune surveillance by key intracellular sensors of viral RNA or DNA are discussed, with a focus on RIG-I-like receptors (RLRs), cyclic GMP–AMP synthase (cGAS) and interferon-γ-inducible protein 16 (IFI16).
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