H
Hyun-Seok Kim
Researcher at Baylor College of Medicine
Publications - 167
Citations - 8417
Hyun-Seok Kim is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 38, co-authored 141 publications receiving 7284 citations. Previous affiliations of Hyun-Seok Kim include University of Minnesota & Yonsei University.
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Journal ArticleDOI
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
Bong-Hyun Ahn,Hyun-Seok Kim,Shiwei Song,In Hye Lee,Jie Liu,Athanassios Vassilopoulos,Chu-Xia Deng,Toren Finkel +7 more
TL;DR: It is shown that Sirt3 functions in vivo to regulate and maintain basal ATP levels and as a regulator of mitochondrial electron transport and implicate protein acetylation as an important regulator of Complex I activity.
Journal ArticleDOI
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.
Rui Hong Wang,Kundan Sengupta,Cuiling Li,Hyun-Seok Kim,Liu Cao,Cuiying Xiao,Sangsoo Kim,Xiaoling Xu,Yin Zheng,Beverly S. Chilton,Rong Jia,Zhi-Ming Zheng,Ettore Appella,Xin Wei Wang,Thomas Ried,Chu-Xia Deng +15 more
TL;DR: It is demonstrated that Sirt1(+/-) mice develop tumors in multiple tissues, whereas activation of SIRT1 by resveratrol treatment reduces tumorigenesis, and it is shown that many human cancers exhibit reduced levels ofSIRT1 compared to normal controls.
Journal ArticleDOI
SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
Hyun-Seok Kim,Krish Patel,Kristi Muldoon-Jacobs,Kheem S. Bisht,Nukhet Aykin-Burns,J. Daniel Pennington,Riet van der Meer,Phuongmai Nguyen,Jason E. Savage,Kjerstin M. Owens,Athanassios Vassilopoulos,Özkan Özden,Seong Hoon Park,Keshav K. Singh,Sarki A. Abdulkadir,Douglas R. Spitz,Chu-Xia Deng,David Gius +17 more
TL;DR: These results identify SIRT3 as a genomically expressed, mitochondria-localized tumor suppressor and human breast and other human cancer specimens exhibit reduced Sirt3 levels.
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SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity
Hyun-Seok Kim,Athanassios Vassilopoulos,Rui Hong Wang,Tyler Lahusen,Zhen Xiao,Xiaoling Xu,Cuiling Li,Timothy D. Veenstra,Bing Li,Hongtao Yu,Junfang Ji,Xin Wei Wang,Seong Hoon Park,Yong I. Cha,David Gius,Chu-Xia Deng +15 more
TL;DR: It is demonstrated that SIRT2 regulates the anaphase-promoting complex/cyclosome activity through deacetylation of its coactivators, APC(CDH1) and CDC20, and is a tumor suppressor through its role in regulating mitosis and genome integrity.
Journal ArticleDOI
Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis
Hyun-Seok Kim,Cuiying Xiao,Rui Hong Wang,Tyler Lahusen,Xiaoling Xu,Athanassios Vassilopoulos,Guelaguetza Vázquez-Ortiz,Won-Il Jeong,Ogyi Park,Sung Hwan Ki,Bin Gao,Chu-Xia Deng +11 more
TL;DR: It is shown that SIRT1 forms a complex with FOXO3a and NRF1 on the SIRT6 promoter and positively regulates expression of SIRT 6, which negatively regulates glycolysis, triglyceride synthesis, and fat metabolism by deacetylating histone Lysine 9 in the promoter of many genes involved in these processes.