H
Hyun T. Kim
Researcher at University of California, San Diego
Publications - 8
Citations - 1417
Hyun T. Kim is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Placebo & Tolerability. The author has an hindex of 7, co-authored 8 publications receiving 1332 citations.
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Journal ArticleDOI
Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials.
Michael Grundman,Ronald C. Petersen,Steven H. Ferris,Ronald G. Thomas,Paul S. Aisen,David A. Bennett,Norman L. Foster,Clifford R. Jack,Douglas Galasko,Rachelle S. Doody,Jeffrey Kaye,Mary Sano,Richard C. Mohs,Serge Gauthier,Hyun T. Kim,Shelia Jin,Arlan N. Schultz,Kimberly Schafer,Ruth A. Mulnard,Christopher H. van Dyck,Jacobo Mintzer,Edward Zamrini,Deborah A. Cahn-Weiner,Leon J. Thal +23 more
TL;DR: Patients with MCI had a predominant memory impairment with relative sparing of other cognitive domains and were intermediate between clinically normal individuals and patients with AD on cognitive and functional ratings.
Journal ArticleDOI
Sex, Apolipoprotein E ε4 Status, and Hippocampal Volume in Mild Cognitive Impairment
Adam S. Fleisher,Michael Grundman,Clifford R. Jack,Ronald C. Petersen,Curtis Taylor,Hyun T. Kim,Denise H. B. Schiller,Victor P. Bagwell,Drahomira Sencakova,Myron F. Weiner,Charles DeCarli,Steven T. DeKosky,Christopher H. van Dyck,Leon J. Thal +13 more
TL;DR: The APOE*E4 genotype status appears to have a greater deleterious effect on gross hippocampal pathology and memory performance in women than in men.
Journal ArticleDOI
Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial.
Michael Grundman,Drahomira Sencakova,Clifford R. Jack,Ronald C. Petersen,Hyun T. Kim,Arlan N. Schultz,Myron F. Weiner,Charles DeCarli,Steven T. DeKosky,Christopher H. van Dyck,Ronald G. Thomas,Leon J. Thal +11 more
TL;DR: MRI hippocampal volume may be a useful correlate of disease severity in MCI subjects and a prognostic indicator of subsequent AD.
Journal ArticleDOI
Hippocampal volume is associated with memory but not nonmemory cognitive performance in patients with mild cognitive impairment
Michael Grundman,Clifford R. Jack,Ronald C. Petersen,Hyun T. Kim,Curtis Taylor,Marina Datvian,Myron F. Weiner,Charles DeCarli,Steven J. DeKosky,Christopher H. van Dyck,Sultan Darvesh,Kristine Yaffe,Jeffrey Kaye,Steven H. Ferris,Ronald G. Thomas,Leon J. Thal +15 more
TL;DR: It is concluded that the relationship between hippocampal volume and risk of AD is likely tied to reduced memory performance and not associated with impairment in nonmemory cognitive domains.
Journal ArticleDOI
A multicenter, randomized, placebo controlled, multiple-dose, safety and pharmacokinetic study of AIT-082 (Neotrofin™) in mild Alzheimer's disease patients
Michael Grundman,Edmund V. Capparelli,Hyun T. Kim,John C. Morris,Martin R. Farlow,E. H. Rubin,Judith L. Heidebrink,Ann Marie Hake,G. Ho,Arlan N. Schultz,Kimberly Schafer,W. Houston,R. G. Thomas,Leon J. Thal +13 more
TL;DR: A phase 1, randomized, double-blind, placebo-controlled, dose escalation study of the purine derivative, AIT-082 was conducted in mild Alzheimer's disease patients to evaluate multiple-dose safety, tolerability, and pharmacokinetics.