Ina Nissen

TL;DR: Surprisingly, the number of mutations between early and late patient samples did not significantly change, and during a total follow-up of 133 patient years, only 2 new mutations appeared, suggesting that the mutation rate in MPN is rather low.

TL;DR: The sequence distributions in DNA-encoded chemical library selections were found to be similar to the ones obtained using 454 technology, thus reinforcing the concept that DNA sequencing is an appropriate avenue for the decoding of library selections.

TL;DR: This study estimates the transmission fitness advantage and the effective reproductive number of B.1.1-CoV-2 variant of Concern in Switzerland and quantifies the variant’s transmission Fitness advantage on a national and a regional scale.

TL;DR: The diversity of genetic variants coexisting within patients across a cohort of 3939 publicly accessible samples and 749 recently sequenced samples from Switzerland is examined and it is found that a small number of patients carry most of the diversity, and that patients with more diversity tend to be older.

TL;DR: It is demonstrated that no one lineage became dominant, pointing against evolution towards general lower virulence, and the framework can be applied to quantify evolution and epidemiology in other locations or for other pathogens based on genomic data.