Maurice Redondo

TL;DR: This study estimates the transmission fitness advantage and the effective reproductive number of B.1.1-CoV-2 variant of Concern in Switzerland and quantifies the variant’s transmission Fitness advantage on a national and a regional scale.

TL;DR: In this article, the authors describe the nationwide coordination and implementation process across laboratories, public health institutions, and researchers, the first results of N501Y-specific variant screening, and the phylogenetic analysis of all available WGS data in Switzerland, that together identified the early introduction events and subsequent community spreading of the VoCs.

TL;DR: The diversity of genetic variants coexisting within patients across a cohort of 3939 publicly accessible samples and 749 recently sequenced samples from Switzerland is examined and it is found that a small number of patients carry most of the diversity, and that patients with more diversity tend to be older.

TL;DR: It is demonstrated that no one lineage became dominant, pointing against evolution towards general lower virulence, and the framework can be applied to quantify evolution and epidemiology in other locations or for other pathogens based on genomic data.

TL;DR: In this paper, the authors estimate the transmission advantage and the effective reproductive number of B.1.7 through time for data from Switzerland between 14.12.2020 and 11.03.2021.