T
Timothy Sykes
Researcher at University of Zurich
Publications - 4
Citations - 49
Timothy Sykes is an academic researcher from University of Zurich. The author has an hindex of 2, co-authored 4 publications receiving 21 citations.
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Journal ArticleDOI
Quantification of the spread of SARS-CoV-2 variant B.1.1.7 in Switzerland.
Chaoran Chen,Sarah Nadeau,Ivan Topolsky,Marc Manceau,Jana S. Huisman,Kim Philipp Jablonski,Lara Fuhrmann,David Dreifuss,Katharina Jahn,Christiane Beckmann,Maurice Redondo,Christoph Noppen,Lorenz Risch,Martin Risch,Nadia Wohlwend,Sinem Kas,Thomas Bodmer,Tim Roloff,Madlen Stange,Adrian Egli,Isabella Eckerle,Laurent Kaiser,Rebecca Denes,Mirjam Feldkamp,Ina Nissen,Natascha Santacroce,Elodie Burcklen,Catharine Aquino,Andreia Cabral de Gouvea,Maria Domenica Moccia,Simon Grüter,Timothy Sykes,Lennart Opitz,Griffin White,Laura Neff,Doris Popovic,Andrea Patrignani,Jay Tracy,Ralph Schlapbach,Emmanouil T. Dermitzakis,Keith Harshman,Ioannis Xenarios,Henri Pegeot,Lorenzo Cerutti,Deborah Penet,Anthony Blin,Melyssa Elies,Christian L. Althaus,Christian Beisel,Niko Beerenwinkel,Martin Ackermann,Tanja Stadler +51 more
TL;DR: This study estimates the transmission fitness advantage and the effective reproductive number of B.1.1-CoV-2 variant of Concern in Switzerland and quantifies the variant’s transmission Fitness advantage on a national and a regional scale.
Posted ContentDOI
HiDRA-seq: High-Throughput SARS-CoV-2 Detection by RNA Barcoding and Amplicon Sequencing
Emilio Yángüez,Griffin White,Susanne Kreutzer,Lennart Opitz,Lucy Poveda,Timothy Sykes,Maria Domenica Moccia,Catharine Aquino,Ralph Schlapbach +8 more
TL;DR: The first version of the HiDRA-seq protocol is described, a rapidly implementable, high throughput, and scalable solution that uses NGS lab infrastructure and reagents for population-scale SARS-CoV-2 testing and can be further improved in the future to increase its sensitivity and to identify other respiratory viruses or analyze individual genetic features associated with disease progression.
Posted ContentDOI
Quantification of the spread of SARS-CoV-2 variant B.1.1.7 in Switzerland
Chaoran Chen,Sarah Nadeau,Ivan Topolsky,Marc Manceau,Jana S. Huisman,Jana S. Huisman,Kim Philipp Jablonski,Lara Fuhrmann,David Dreifuss,Katharina Jahn,Christiane Beckmann,Maurice Redondo,Olivier Kobel,Christoph Noppen,Lorenz Risch,Martin Risch,Nadia Wohlwend,Sinem Kas,Thomas Bodmer,Tim Roloff,Tim Roloff,Tim Roloff,Madlen Stange,Madlen Stange,Madlen Stange,Adrian Egli,Adrian Egli,Isabella Eckerle,Isabella Eckerle,Laurent Kaiser,Laurent Kaiser,Rebecca Denes,Mirjam Feldkamp,Ina Nissen,Natascha Santacroce,Elodie Burcklen,Catharine Aquino,Andreia Cabral de Gouvea,Maria Domenica Moccia,Simon Grüter,Timothy Sykes,Lennart Opitz,Griffin White,Laura Neff,Doris Popovic,Andrea Patrignani,Jay Tracy,Ralph Schlapbach,Emmanouil T. Dermitzakis,Keith Harshman,Ioannis Xenarios,Henri Pegeot,Lorenzo Cerutti,Deborah Penet,Anthony Blin,Melyssa Elies,Christian L. Althaus,Christian Beisel,Niko Beerenwinkel,Martin Ackermann,Tanja Stadler +60 more
TL;DR: In this paper, the authors estimate the transmission advantage and the effective reproductive number of B.1.7 through time for data from Switzerland between 14.12.2020 and 11.03.2021.
Journal ArticleDOI
Mapping Spatial Genetic Landscapes in Tissue Sections through Microscale Integration of Sampling Methodology into Genomic Workflows.
Lena Voith von Voithenberg,Aditya Kashyap,Lennart Opitz,Catharine Aquino,Timothy Sykes,Maike Nieser,Lorenzo F. T. Petrini,Nadia Enrriquez Casimiro,Xander F. van Kooten,Saskia Biskup,Ralph Schlapbach,Peter Schraml,Govind V. Kaigala +12 more
TL;DR: The integrated workflow-GeneScape-is used to evaluate heterogeneity in a metastatic mammary carcinoma, showing distinct single nucleotide variants and copy number variations in different tumor tissue regions, suggesting the polyclonal origin of the metastasis as well as development driven by multiple location-specific drivers.