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Ingeborg Krägeloh-Mann
Researcher at Boston Children's Hospital
Publications - 205
Citations - 9692
Ingeborg Krägeloh-Mann is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Metachromatic leukodystrophy & Leukodystrophy. The author has an hindex of 49, co-authored 195 publications receiving 8292 citations. Previous affiliations of Ingeborg Krägeloh-Mann include University of Tübingen.
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Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation
Gert C. Scheper,Thom van der Klok,Rob J van Andel,Carola G.M. van Berkel,Marie Sissler,Joél Smet,Tatjana I Muravina,Sergey V Serkov,Graziella Uziel,Marianna Bugiani,Raphael Schiffmann,Ingeborg Krägeloh-Mann,Jan A.M. Smeitink,Catherine Florentz,Rudy Van Coster,Jan C. Pronk,Marjo S. van der Knaap +16 more
TL;DR: It is surprised to find that activities of mitochondrial complexes from fibroblasts and lymphoblasts derived from affected individuals were normal, as determined by different assays.
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Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders.
Markus Wolff,Katrine M Johannesen,Ulrike B. S. Hedrich,Silvia Masnada,Guido Rubboli,Elena Gardella,Gaetan Lesca,Gaetan Lesca,Dorothée Ville,Mathieu Milh,Laurent Villard,Alexandra Afenjar,Sandra Chantot-Bastaraud,Cyril Mignot,Caroline Lardennois,Caroline Nava,Niklas Schwarz,Marion Gérard,Laurence Perrin,Diane Doummar,Stéphane Auvin,Maria J Miranda,Maja Hempel,Eva H. Brilstra,Nine V A M Knoers,Nienke E. Verbeek,Marjan J. A. van Kempen,Kees P.J. Braun,Grazia M.S. Mancini,Saskia Biskup,Konstanze Hörtnagel,Miriam Döcker,Thomas Bast,Tobias Loddenkemper,Lily C. Wong-Kisiel,Friedrich A. M. Baumeister,Walid Fazeli,Pasquale Striano,Robertino Dilena,Elena Fontana,Federico Zara,Gerhard Kurlemann,Joerg Klepper,Jess G. Thoene,Daniel H. Arndt,Nicolas Deconinck,Thomas Schmitt-Mechelke,Oliver Maier,Hiltrud Muhle,Beverly Wical,Claudio Finetti,Reinhard Brückner,Joachim Pietz,Günther Golla,Dinesh V Jillella,Karen Markussen Linnet,Perrine Charles,Ute Moog,Eve Õiglane-Shlik,John F Mantovani,Kristen Park,Marie Deprez,Damien Lederer,Sandrine Mary,Emmanuel Scalais,Laila Selim,Rudy Van Coster,Lieven Lagae,Marina Nikanorova,Helle Hjalgrim,G. Christoph Korenke,Marina Trivisano,Nicola Specchio,Berten Ceulemans,Thomas Dorn,Katherine L. Helbig,Katia Hardies,Hannah Stamberger,Peter De Jonghe,Sarah Weckhuysen,Johannes R. Lemke,Ingeborg Krägeloh-Mann,Ingo Helbig,Ingo Helbig,Gerhard Kluger,Holger Lerche,Rikke S. Møller +86 more
TL;DR: Clinical and experimental data suggest a correlation between age at disease onset, response to sodium channel blockers and the functional properties of mutations in children with SCN2A-related epilepsy, and suggest that mutations associated with early infantile epilepsy result in increased sodium channel activity with gain-of-function.
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Two types of ipsilateral reorganization in congenital hemiparesis: a TMS and fMRI study.
Martin Staudt,Wolfgang Grodd,Christian Gerloff,Michael Erb,Jutta Stitz,Ingeborg Krägeloh-Mann +5 more
TL;DR: Evidence is provided that the type of cortico-spinal reorganization depends on the extent of the brain lesion, and it is proposed that involvement of the ipsilateral hemisphere can be of the premotor type, i.e. without ipsilaterally motor projections but with significant activation of ips bilateral premotor areas.
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The role of magnetic resonance imaging in elucidating the pathogenesis of cerebral palsy: a systematic review.
TL;DR: A systematic review of studies using MRI in children with CP was performed according to pathogenetic patterns characterizing different timing periods of occurence of the lesions, and with respect to gestational age (term vs preterm) and CP subtypes.
Journal ArticleDOI
Decreasing prevalence in cerebral palsy: a multi-site European population-based study, 1980 to 2003.
Elodie Sellier,Mary Jane Platt,Guro L. Andersen,Ingeborg Krägeloh-Mann,Javier De La Cruz,Christine Cans +5 more
TL;DR: To monitor the trends in prevalence of cerebral palsy by birthweight in Europe, 1980 to 2003, data is collected on children born in Europe between 1980 and 2003.