W
Walid Fazeli
Researcher at University of Cologne
Publications - 20
Citations - 584
Walid Fazeli is an academic researcher from University of Cologne. The author has contributed to research in topics: Epilepsy & Medicine. The author has an hindex of 6, co-authored 14 publications receiving 347 citations. Previous affiliations of Walid Fazeli include University Hospital Bonn.
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Journal ArticleDOI
Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders.
Markus Wolff,Katrine M Johannesen,Ulrike B. S. Hedrich,Silvia Masnada,Guido Rubboli,Elena Gardella,Gaetan Lesca,Gaetan Lesca,Dorothée Ville,Mathieu Milh,Laurent Villard,Alexandra Afenjar,Sandra Chantot-Bastaraud,Cyril Mignot,Caroline Lardennois,Caroline Nava,Niklas Schwarz,Marion Gérard,Laurence Perrin,Diane Doummar,Stéphane Auvin,Maria J Miranda,Maja Hempel,Eva H. Brilstra,Nine V A M Knoers,Nienke E. Verbeek,Marjan J. A. van Kempen,Kees P.J. Braun,Grazia M.S. Mancini,Saskia Biskup,Konstanze Hörtnagel,Miriam Döcker,Thomas Bast,Tobias Loddenkemper,Lily C. Wong-Kisiel,Friedrich A. M. Baumeister,Walid Fazeli,Pasquale Striano,Robertino Dilena,Elena Fontana,Federico Zara,Gerhard Kurlemann,Joerg Klepper,Jess G. Thoene,Daniel H. Arndt,Nicolas Deconinck,Thomas Schmitt-Mechelke,Oliver Maier,Hiltrud Muhle,Beverly Wical,Claudio Finetti,Reinhard Brückner,Joachim Pietz,Günther Golla,Dinesh V Jillella,Karen Markussen Linnet,Perrine Charles,Ute Moog,Eve Õiglane-Shlik,John F Mantovani,Kristen Park,Marie Deprez,Damien Lederer,Sandrine Mary,Emmanuel Scalais,Laila Selim,Rudy Van Coster,Lieven Lagae,Marina Nikanorova,Helle Hjalgrim,G. Christoph Korenke,Marina Trivisano,Nicola Specchio,Berten Ceulemans,Thomas Dorn,Katherine L. Helbig,Katia Hardies,Hannah Stamberger,Peter De Jonghe,Sarah Weckhuysen,Johannes R. Lemke,Ingeborg Krägeloh-Mann,Ingo Helbig,Ingo Helbig,Gerhard Kluger,Holger Lerche,Rikke S. Møller +86 more
TL;DR: Clinical and experimental data suggest a correlation between age at disease onset, response to sodium channel blockers and the functional properties of mutations in children with SCN2A-related epilepsy, and suggest that mutations associated with early infantile epilepsy result in increased sodium channel activity with gain-of-function.
Journal ArticleDOI
Genotype-phenotype correlations in SCN8A-related disorders reveal prognostic and therapeutic implications.
Katrine M Johannesen,Yuanyuan Liu,Mahmoud Koko,Cathrine E Gjerulfsen,Lukas Sonnenberg,Julian Schubert,Christina Fenger,Ahmed Eltokhi,Maert Rannap,Nils A Koch,Stephan Lauxmann,Johanna Krüger,Josua Kegele,Laura Canafoglia,Silvana Franceschetti,Thomas U. Mayer,Johannes Rebstock,Pia Zacher,Susanne Ruf,Michael Alber,Katalin Sterbova,Petra Laššuthová,Marketa Vlckova,Johannes R. Lemke,Konrad Platzer,Ilona Krey,Constanze Heine,Dagmar Wieczorek,Judith Kroell-Seger,Caroline Lund,Karl Martin Klein,P Y Billie Au,Jong M. Rho,Alice W Ho,Silvia Masnada,Pierangelo Veggiotti,Pierangelo Veggiotti,Lucio Giordano,Patrizia Accorsi,Christina E. Hoei-Hansen,Christina E. Hoei-Hansen,Pasquale Striano,Federico Zara,Helene Verhelst,Judith S. Verhoeven,Bert van der Zwaag,Aster V. E. Harder,Eva H. Brilstra,Manuela Pendziwiat,Sebastian Lebon,María Vaccarezza,Ngoc Minh Le,Jakob Christensen,Sabine Grønborg,Stephen W. Scherer,Stephen W. Scherer,Jennifer L. Howe,Walid Fazeli,Walid Fazeli,Katherine B. Howell,Richard J. Leventer,Chloe A Stutterd,Sonja Walsh,Marion Gérard,Bénédicte Gérard,Sara Matricardi,Claudia M Bonardi,Stefano Sartori,Andrea Berger,Dorota Hoffman-Zacharska,Massimo Mastrangelo,Francesca Darra,Arve Vøllo,M. Mahdi Motazacker,Phillis Lakeman,Mathilde Nizon,Cornelia Betzler,Cecilia Altuzarra,Roseline Caume,Agathe Roubertie,Philippe Gelisse,Carla Marini,Renzo Guerrini,Frederic Bilan,Daniel Tibussek,Margarete Koch-Hogrebe,M Scott Perry,Shoji Ichikawa,Elena L. Dadali,A. A. Sharkov,Irina Mishina,Mikhail Abramov,Ilya V. Kanivets,Sergey Korostelev,Sergey Kutsev,Karen E. Wain,Nancy Eisenhauer,Monisa D. Wagner,Juliann M. Savatt,Karen Müller-Schlüter,Haim Bassan,Artem Borovikov,Marie-Cécile Nassogne,Anne Destrée,An-Sofie Schoonjans,Marije Meuwissen,Marga Buzatu,Anna Jansen,Emmanuel Scalais,Siddharth Srivastava,Wen-Hann Tan,Heather E. Olson,Tobias Loddenkemper,Annapurna Poduri,Katherine L. Helbig,Ingo Helbig,Mark Fitzgerald,Ethan M. Goldberg,Timo Roser,Ingo Borggraefe,Tobias Brünger,Patrick May,Dennis Lal,Damien Lederer,Guido Rubboli,Henrike O. Heyne,Gaetan Lesca,Gaetan Lesca,Ulrike B. S. Hedrich,Jan Benda,Elena Gardella,Holger Lerche,Rikke S. Møller +132 more
TL;DR: In this article, the genotype-phenotype correlations in 392 individuals carrying disease-causing variants in SCN8A, encoding the voltage-gated Na+ channel NaV1.6, were reported.
Journal ArticleDOI
Clinical and genetic spectrum of SCN2A-associated episodic ataxia.
Niklas Schwarz,Thomas Bast,Eija Gaily,G Golla,Kathleen M. Gorman,Lyn R. Griffiths,Andreas Hahn,Juliette Hukin,Mary D. King,Christian Korff,Maria J Miranda,Rikke S. Møller,Bernd A. Neubauer,Robert A. Smith,Thomas Smol,Pasquale Striano,B Stroud,M Vaccarezza,Gerhard Kluger,Holger Lerche,Walid Fazeli +20 more
TL;DR: The heterogeneous clinical spectrum of SCN2A-associated EA is described, two mutational hotspots are identified and positive effects of acetazolamide are shown in about 50%.
Posted ContentDOI
Genotype-phenotype correlations in SCN8A-related disorders reveal prognostic and therapeutic implications
Katrine M Johannesen,Yuanyuan Liu,Cathrine E Gjerulfsen,Mahmoud Koko,Lukas Sonnenberg,Julian Schubert,Christina Fenger,Ahmed Eltokhi,Maert Rannap,Nils A Koch,Stephan Lauxmann,Johanna Krüger,Josua Kegele,Laura Canafoglia,Silvana Franceschetti,Thomas U. Mayer,Johannes Rebstock,Pia Zacher,Susanne Ruf,Michael Alber,Katalin Sterbova,Petra Laššuthová,Marketa Vlckova,Johannes R. Lemke,Ilona Krey,Constanze Heine,Dagmar Wieczorek,Judith Kroell-Seger,Caroline Lund,Karl Martin Klein,P Y Billie Au,Jong M. Rho,Alice W Ho,Silvia Masnada,Pierangelo Veggiotti,Pierangelo Veggiotti,Lucio Giordano,Patrizia Accorsi,Christina E. Hoei-Hansen,Christina E. Hoei-Hansen,Pasquale Striano,Federico Zara,Helene Verhelst,Judith S. Verhoeven,Bert van der Zwaag,Aster V. E. Harder,Eva H. Brilstra,Manuela Pendziwiat,Sebastian Lebon,María Vaccarezza,Ngoc Minh Le,Jakob Christensen,Mette U Schmidt-Petersen,Sabine Grønborg,Stephen W. Scherer,Stephen W. Scherer,Jennifer L. Howe,Walid Fazeli,Walid Fazeli,Katherine B. Howell,Richard J. Leventer,Chloe A Stutterd,Sonja Walsh,Marion Gérard,Bénédicte Gérard,Sara Matricardi,Claudia M Bonardi,Stefano Sartori,Andrea Berger,Dorota Hoffman-Zacharska,Massimo Mastrangelo,Francesca Darra,Arve Vøllo,M. Mahdi Motazacker,Phillis Lakeman,Mathilde Nizon,Cornelia Betzler,Cecilia Altuzarra,Roseline Caume,Agathe Roubertie,Philippe Gelisse,Carla Marini,Renzo Guerrini,Frédéric Bilan,Daniel Tibussek,Margarete Koch-Hogrebe,M Scott Perry,Shoji Ichikawa,Elena L. Dadali,A. A. Sharkov,Irina Mishina,Mikhail Abramov,Ilya V. Kanivets,Sergey Korostelev,Sergey Kutsev,Karen E. Wain,Nancy Eisenhauer,Monisa D. Wagner,Juliann M. Savatt,Karen Müller-Schlüter,Haim Bassan,Artem Borovikov,Marie-Cécile Nassogne,Anne Destrée,An-Sofie Schoonjans,Marije Meuwissen,Marga Buzatu,Anna Jansen,Emmanuel Scalais,Siddharth Srivastava,Wen-Hann Tan,Heather E. Olson,Tobias Loddenkemper,Annapurna Poduri,Katherine L. Helbig,Ingo Helbig,Mark Fitzgerald,Ethan M. Goldberg,Timo Roser,Ingo Borggraefe,Tobias Brünger,Patrick May,Dennis Lal,Damien Lederer,Guido Rubboli,Gaetan Lesca,Gaetan Lesca,Ulrike B. S. Hedrich,Jan Benda,Elena Gardella,Holger Lerche,Rikke S. Møller +131 more
TL;DR: In this paper, the genotype-phenotype correlations in 433 individuals carrying disease-causing variants in SCN8A, encoding the voltage-gated Na+ channel NaV1.6.
Journal ArticleDOI
Activity of Na V 1.2 promotes neurodegeneration in an animal model of multiple sclerosis.
Benjamin Schattling,Walid Fazeli,Birgit Engeland,Yuanyuan Liu,Holger Lerche,Dirk Isbrandt,Manuel A. Friese +6 more
TL;DR: This study shows that increased neuronal NaV1.2 activity exacerbates inflammation-induced neurodegeneration irrespective of immune cell alterations and identifies NaV 1.2 as a promising neuroprotective drug target in multiple sclerosis.