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Ion I. Moraru
Researcher at University of Connecticut Health Center
Publications - 72
Citations - 3411
Ion I. Moraru is an academic researcher from University of Connecticut Health Center. The author has contributed to research in topics: SBML & Software. The author has an hindex of 28, co-authored 68 publications receiving 2985 citations. Previous affiliations of Ion I. Moraru include Carol Davila University of Medicine and Pharmacy & University of Connecticut.
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Journal ArticleDOI
Cell Shape and Negative Links in Regulatory Motifs Together Control Spatial Information Flow in Signaling Networks
Susana R. Neves,Panayiotis Tsokas,Anamika Sarkar,Elizabeth A. Grace,Padmini Rangamani,Stephen M. Taubenfeld,Cristina M. Alberini,James C. Schaff,Robert D. Blitzer,Ion I. Moraru,Ravi Iyengar +10 more
TL;DR: A mechanism by which cellular geometry, the presence of regulatory loops with negative regulators, and key reaction rates all together control spatial information transfer and microdomain characteristics within cells is suggested.
Journal ArticleDOI
NMRbox: A Resource for Biomolecular NMR Computation
Mark W. Maciejewski,Adam D. Schuyler,Michael R. Gryk,Ion I. Moraru,Pedro R Romero,Eldon L. Ulrich,Hamid R. Eghbalnia,Miron Livny,Frank Delaglio,Jeffrey C. Hoch +9 more
TL;DR: NMRbox is a shared resource for NMR software and computation that employs virtualization to provide a comprehensive software environment preconfigured with hundreds of software packages, available as a downloadable virtual machine or as a Platform-as-a-Service supported by a dedicated compute cloud.
Journal ArticleDOI
Virtual cell modelling and simulation software environment
Ion I. Moraru,James C. Schaff,Boris M. Slepchenko,Michael L. Blinov,Frank Morgan,Anuradha Lakshminarayana,Fei Gao,Ye Li,Leslie M. Loew +8 more
TL;DR: The Virtual Cell is now open source, with its native model encoding language (VCML) being a public specification, which stands as the basis for a new generation of more customised, experiment-centric modelling tools using a new plug-in based platform.
Journal ArticleDOI
Reproducible computational biology experiments with SED-ML--the Simulation Experiment Description Markup Language.
Dagmar Waltemath,Richard R. Adams,Frank Bergmann,Michael Hucka,Fedor A. Kolpakov,Andrew K. Miller,Ion I. Moraru,David P. Nickerson,Sven Sahle,Jacky L. Snoep,Jacky L. Snoep,Jacky L. Snoep,Nicolas Le Novère +12 more
TL;DR: With SED-ML, software can exchange simulation experiment descriptions, enabling the validation and reuse of simulation experiments in different tools, and Authors of papers reporting simulation experiments can make their simulation protocols available for other scientists to reproduce the results.
Journal ArticleDOI
Topology of the mitochondrial inner membrane: dynamics and bioenergetic implications.
Carmen A. Mannella,Douglas R. Pfeiffer,Patrick C. Bradshaw,Ion I. Moraru,Boris M. Slepchenko,Leslie M. Loew,Chyongere Hsieh,Karolyn F. Buttle,Michael Marko +8 more
TL;DR: Computer modeling studies using the “Virtual Cell” program suggest that the shape of the inner membrane can influence mitochondrial function, and simulations indicate that narrow cristae junctions restrict diffusion between intracristal and external compartments, causing depletion of ADP and decreased ATP output inside the crists.