P
Philip T. LoVerde
Researcher at University of Texas Health Science Center at San Antonio
Publications - 167
Citations - 7295
Philip T. LoVerde is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Schistosoma mansoni & Gene. The author has an hindex of 45, co-authored 163 publications receiving 6823 citations. Previous affiliations of Philip T. LoVerde include State University of New York System & Greehey Children's Cancer Research Institute.
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Journal ArticleDOI
The genome of the blood fluke Schistosoma mansoni
Matthew Berriman,Brian J. Haas,Brian J. Haas,Philip T. LoVerde,R. Alan Wilson,Gary P. Dillon,Gustavo C. Cerqueira,Susan T. Mashiyama,Bissan Al-Lazikani,Luiza F. Andrade,Peter D. Ashton,Martin Aslett,Daniella Castanheira Bartholomeu,Daniella Castanheira Bartholomeu,Gaëlle Blandin,Conor R. Caffrey,Avril Coghlan,Richard M.R. Coulson,Tim A. Day,Arthur L. Delcher,Ricardo DeMarco,Ricardo DeMarco,Appoliniare Djikeng,Tina Eyre,John Gamble,Elodie Ghedin,Elodie Ghedin,Yong-Hong Gu,Christiane Hertz-Fowler,Hirohisha Hirai,Yuriko Hirai,Robin Houston,Alasdair Ivens,David A. Johnston,David A. Johnston,Daniela R. Lacerda,Daniela R. Lacerda,Camila D. S. Macedo,Paul McVeigh,Zemin Ning,Guilherme Oliveira,John P. Overington,Julian Parkhill,Mihaela Pertea,Raymond J. Pierce,Anna V. Protasio,Michael A. Quail,Marie-Adèle Rajandream,Jane Rogers,Mohammed Sajid,Steven L. Salzberg,Mario Stanke,Adrian Tivey,Owen White,Owen White,David L. Williams,David L. Williams,Jennifer R. Wortman,Jennifer R. Wortman,Wenjie Wu,Mostafa Zamanian,Adhemar Zerlotini,Claire M. Fraser-Liggett,Claire M. Fraser-Liggett,Barclay G. Barrell,Najib M. El-Sayed,Najib M. El-Sayed +66 more
TL;DR: Analysis of the 363 megabase nuclear genome of the blood fluke, the first sequenced flatworm, and a representative of the Lophotrochozoa offers insights into early events in the evolution of the animals, including the development of a body pattern with bilateral symmetry, and theDevelopment of tissues into organs.
Journal ArticleDOI
A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni.
Anna V. Protasio,Isheng J. Tsai,A K Babbage,Sarah Nichol,Martin Hunt,Martin Aslett,Nishadi De Silva,Giles S. Velarde,Tim J. Anderson,Richard Clark,Claire Davidson,Gary P. Dillon,Nancy Holroyd,Philip T. LoVerde,Christine Lloyd,Jacquelline McQuillan,Guilherme Oliveira,Thomas D. Otto,Sophia J. Parker-Manuel,Michael A. Quail,R. Alan Wilson,Adhemar Zerlotini,David W. Dunne,Matthew Berriman +23 more
TL;DR: The upgraded genome of Schistosoma mansoni will form a fundamental dataset to underpin further advances in schistosome research and is consolidated into a searchable format within the GeneDB and SchistoDB databases.
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A Cost of Increased Early Reproductive Effort in the Snail Biomphalaria glabrata
TL;DR: Snails exposed to the trematode parasite, Schistosoma mansoni, are shown to experience an early reproductive increase soon after exposure to S. mansoni whether or not they become parasitized, and snails which were exposed but not parasitized showed reduced future fecundity as a result of their high early reproductive output.
Journal ArticleDOI
Tools for diagnosis, monitoring and screening of Schistosoma infections utilizing lateral-flow based assays and upconverting phosphor labels
Paul L. A. M. Corstjens,Claudia J. de Dood,Dieuwke Kornelis,Elisa M. Tjon Kon Fat,R. Alan Wilson,Thomas M. Kariuki,Ruth Nyakundi,Philip T. LoVerde,William R. Abrams,Hans J. Tanke,Lisette van Lieshout,André M. Deelder,Govert J. van Dam +12 more
TL;DR: The different UCP-LF based assays for diagnosis of schistosomiasis provide a collection of tests with relatively low complexity and high sensitivity, covering the full range of diagnostics needed in control programmes for mapping, screening and monitoring.
Journal ArticleDOI
Genetic and Molecular Basis of Drug Resistance and Species-Specific Drug Action in Schistosome Parasites
Claudia L L Valentim,Claudia L L Valentim,Donato Cioli,Frédéric D. Chevalier,Xiaohang Cao,Alexander B. Taylor,Stephen P. Holloway,Livia Pica-Mattoccia,Alessandra Guidi,Annalisa Basso,Isheng J. Tsai,Matthew Berriman,Claudia Carvalho-Queiroz,Marcio Almeida,Hector R. Aguilar,Doug E. Frantz,P. John Hart,P. John Hart,Philip T. LoVerde,Tim J. Anderson +19 more
TL;DR: Results demonstrate the utility of linkage mapping in a human helminth parasite, while crystallographic analyses of protein-drug interactions illuminate the mode of drug action and provide a framework for rational design of oxamniquine derivatives that kill both S. mansoni and S. haematobium.