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Isil Barlan
Researcher at Marmara University
Publications - 126
Citations - 4980
Isil Barlan is an academic researcher from Marmara University. The author has contributed to research in topics: Asthma & Allergy. The author has an hindex of 32, co-authored 124 publications receiving 4470 citations.
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International consensus document (icon): common variable immunodeficiency disorders
Francisco A. Bonilla,Isil Barlan,Helen Chapel,Beatriz Tavares Costa-Carvalho,Charlotte Cunningham-Rundles,M. Teresa de la Morena,Francisco J. Espinosa-Rosales,Lennart Hammarström,Shigeaki Nonoyama,Isabella Quinti,John M. Routes,Mimi L.K. Tang,Klaus Warnatz +12 more
TL;DR: The International Collaboration in Asthma, Allergy and Immunology initiated an international coalition among the American Academy of Allergy, Asthma & Immunology; the European Academy of allergy and Clinical Immunology, and the World Allergy Organization on common variable immunodeficiency.
Journal ArticleDOI
Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome
Karin R. Engelhardt,Sean A. McGhee,Sabine Winkler,A. Sassi,Cristina Woellner,G Lopez-Herrera,A. W. Chen,Hong Sook Kim,Maria Garcia Lloret,Ilka Schulze,Stephan Ehl,Jens Thiel,Dietmar Pfeifer,Hendrik Veelken,Tim Niehues,Kathrin Siepermann,S Weinspach,Ismail Reisli,Sevgi Keles,Ferah Genel,Necil Kutuculer,Yildiz Camcioglu,Ayper Somer,Elif Karakoc-Aydiner,Isil Barlan,Andrew R. Gennery,Ayse Metin,Aydan Değerliyurt,Maria Cristina Pietrogrande,Mehdi Yeganeh,Zeina Baz,Salem Al-Tamemi,Christoph Klein,Jennifer M. Puck,Steven M. Holland,Edward R.B. McCabe,Bodo Grimbacher,Talal A. Chatila +37 more
TL;DR: In this paper, the authors identify a gene that is mutated or deleted in autosomal recessive hyper-IgE syndrome and perform genome-wide single nucleotide polymorphism analysis to locate copy number variations and homozygous haplotypes.
Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome (vol 124, pg 1289, 2009)
Karin R. Engelhardt,Sean A. McGhee,S. Winkler,A. Sassi,Cristina Woellner,G Lopez-Herrera,A. W. Chen,HS Kim,Maria Garcia Lloret,Ilka Schulze,Stephan Ehl,Jens Thiel,Dietmar Pfeifer,Hendrik Veelken,Tim Niehues,Kathrin Siepermann,S Weinspach,Ismail Reisli,Sevgi Keles,Ferah Genel,N Kutuculer,Yildiz Camcioglu,Ayper Somer,Elif Karakoc-Aydiner,Isil Barlan,Andrew R. Gennery,Ayse Metin,Aydan Değerliyurt,Maria Cristina Pietrogrande,Mehdi Yeganeh,Zeina Baz,Salem Al-Tamemi,Christoph Klein,Jennifer M. Puck,Steven M. Holland,Erb McCabe,Bodo Grimbacher,Talal A. Chatila +37 more
Journal ArticleDOI
Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K
Carrie L. Lucas,Yu Zhang,Anthony Venida,Ying Wang,Jason D. Hughes,Joshua J McElwee,Morgan Butrick,Helen F. Matthews,Susan Price,Matthew Biancalana,Xiaochuan Wang,Michael Richards,Tamara C. Pozos,Isil Barlan,Ahmet Ozen,V. Koneti Rao,Helen C. Su,Michael J. Lenardo +17 more
TL;DR: Human patients with immunodeficiency and lymphoproliferation with skewing of CD8+ T cells toward terminally differentiated and senescent effector cells that have shortened telomeres are identified.
Journal ArticleDOI
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation
Haifa H. Jabara,Douglas R. McDonald,Erin Janssen,Michel J. Massaad,Narayanaswamy Ramesh,Arturo Borzutzky,Ingrid Rauter,Halli Benson,Lynda C. Schneider,Sachin N. Baxi,Mike Recher,Luigi D. Notarangelo,Rima Wakim,Ghassan Dbaibo,Majed Dasouki,Waleed Al-Herz,Isil Barlan,Safa Baris,Necil Kutukculer,Hans D. Ochs,Alessandro Plebani,Maria Kanariou,Gérard Lefranc,Ismail Reisli,Katherine A. Fitzgerald,Douglas T. Golenbock,John P. Manis,Sevgi Keles,Sevgi Keles,Reuben Ceja,Talal A. Chatila,Raif S. Geha +31 more
TL;DR: DOCK8 functions as an adaptor in a TLR9-MyD88 signaling pathway in B cells, which drives B cell proliferation and immunoglobulin production driven by Toll-like receptor 9.