J
J. Andrew Berglund
Researcher at University at Albany, SUNY
Publications - 60
Citations - 4121
J. Andrew Berglund is an academic researcher from University at Albany, SUNY. The author has contributed to research in topics: RNA splicing & RNA. The author has an hindex of 24, co-authored 56 publications receiving 3678 citations. Previous affiliations of J. Andrew Berglund include University of Oregon & State University of New York System.
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Journal ArticleDOI
The genome sequence of the filamentous fungus Neurospora crassa
James E. Galagan,Sarah E. Calvo,Katherine A. Borkovich,Eric U. Selker,Nick O. Read,David B. Jaffe,William Fitzhugh,Li-Jun Ma,Serge Smirnov,Seth Purcell,Bushra Rehman,Timothy Elkins,Reinhard Engels,Shunguang Wang,Cydney B. Nielsen,Jonathan Butler,Matthew G. Endrizzi,Dayong Qui,Peter Ianakiev,Deborah Bell-Pedersen,Mary Anne Nelson,Margaret Werner-Washburne,Claude P. Selitrennikoff,John A. Kinsey,Edward L. Braun,Alex Zelter,Alex Zelter,Ulrich Schulte,Gregory O. Kothe,Gregory Jedd,Werner Mewes,Chuck Staben,Edward M. Marcotte,David Greenberg,Alice Roy,Karen Foley,Jerome Naylor,Nicole Stange-Thomann,Robert Barrett,Sante Gnerre,Michael Kamal,Manolis Kamvysselis,Evan Mauceli,Cord Bielke,Stephen Rudd,Dmitrij Frishman,Svetlana Krystofova,Carolyn G. Rasmussen,Robert L. Metzenberg,David D. Perkins,Scott Kroken,Carlo Cogoni,Giuseppe Macino,David E. A. Catcheside,Weixi Li,Robert J. Pratt,Stephen A. Osmani,Colin P.C. DeSouza,Louise Glass,Marc J. Orbach,J. Andrew Berglund,Rodger B. Voelker,Oded Yarden,Michael Plamann,Stephan Seiler,Jay C. Dunlap,Alan Radford,Rodolfo Aramayo,Donald O. Natvig,Lisa A. Alex,Gertrud Mannhaupt,Daniel J. Ebbole,Michael Freitag,Ian T. Paulsen,Matthew S. Sachs,Eric S. Lander,Chad Nusbaum,Bruce W. Birren +77 more
TL;DR: A high-quality draft sequence of the N. crassa genome is reported, suggesting that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.
Journal ArticleDOI
Role of RNA structure in regulating pre-mRNA splicing
M. Bryan Warf,J. Andrew Berglund +1 more
TL;DR: The role of RNA structure deserves more consideration when thinking about splicing mechanisms, as it can inhibit or aid binding of spliceosomal components to the pre-mRNA, or can increase splicing efficiency by bringing important sequences into close proximity.
Journal ArticleDOI
Pentamidine reverses the splicing defects associated with myotonic dystrophy
TL;DR: Pentamidine was able to reverse the missplicing of 2 pre-mRNAs affected in DM, whereas neomycin B had no effect, and pentamidine significantly reduced the formation of ribonuclear foci in tissue culture cells, releasing MBNL1 from the focuses in the treated cells.
Journal ArticleDOI
MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T
M. Bryan Warf,J. Andrew Berglund +1 more
TL;DR: In vivo splicing results indicate that MBNL-regulated splicing is dependent upon the formation of stem–loops recognized by MBNL, and results suggest thatMBNL may bind all of its RNA substrates, both normal and pathogenic, as structured stem-loops containing pyrimidine mismatches.
Journal ArticleDOI
The structural basis of myotonic dystrophy from the crystal structure of CUG repeats
TL;DR: To better understand the structural basis of DM type 1, the x-ray crystal structure of an 18-bp RNA containing six CUG repeats was determined to 1.58-A resolution, providing a high-resolution view of a toxic, trinucleotide repeat RNA.