S
Stephan Seiler
Researcher at University of Göttingen
Publications - 30
Citations - 4676
Stephan Seiler is an academic researcher from University of Göttingen. The author has contributed to research in topics: Neurospora crassa & Cell polarity. The author has an hindex of 27, co-authored 30 publications receiving 4487 citations. Previous affiliations of Stephan Seiler include Ludwig Maximilian University of Munich & University of Missouri–Kansas City.
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Journal ArticleDOI
The genome sequence of the filamentous fungus Neurospora crassa
James E. Galagan,Sarah E. Calvo,Katherine A. Borkovich,Eric U. Selker,Nick O. Read,David B. Jaffe,William Fitzhugh,Li-Jun Ma,Serge Smirnov,Seth Purcell,Bushra Rehman,Timothy Elkins,Reinhard Engels,Shunguang Wang,Cydney B. Nielsen,Jonathan Butler,Matthew G. Endrizzi,Dayong Qui,Peter Ianakiev,Deborah Bell-Pedersen,Mary Anne Nelson,Margaret Werner-Washburne,Claude P. Selitrennikoff,John A. Kinsey,Edward L. Braun,Alex Zelter,Alex Zelter,Ulrich Schulte,Gregory O. Kothe,Gregory Jedd,Werner Mewes,Chuck Staben,Edward M. Marcotte,David Greenberg,Alice Roy,Karen Foley,Jerome Naylor,Nicole Stange-Thomann,Robert Barrett,Sante Gnerre,Michael Kamal,Manolis Kamvysselis,Evan Mauceli,Cord Bielke,Stephen Rudd,Dmitrij Frishman,Svetlana Krystofova,Carolyn G. Rasmussen,Robert L. Metzenberg,David D. Perkins,Scott Kroken,Carlo Cogoni,Giuseppe Macino,David E. A. Catcheside,Weixi Li,Robert J. Pratt,Stephen A. Osmani,Colin P.C. DeSouza,Louise Glass,Marc J. Orbach,J. Andrew Berglund,Rodger B. Voelker,Oded Yarden,Michael Plamann,Stephan Seiler,Jay C. Dunlap,Alan Radford,Rodolfo Aramayo,Donald O. Natvig,Lisa A. Alex,Gertrud Mannhaupt,Daniel J. Ebbole,Michael Freitag,Ian T. Paulsen,Matthew S. Sachs,Eric S. Lander,Chad Nusbaum,Bruce W. Birren +77 more
TL;DR: A high-quality draft sequence of the N. crassa genome is reported, suggesting that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.
Journal ArticleDOI
Lessons from the Genome Sequence of Neurospora crassa: Tracing the Path from Genomic Blueprint to Multicellular Organism
Katherine A. Borkovich,Lisa A. Alex,Oded Yarden,Michael Freitag,Gloria E. Turner,Nick D. Read,Stephan Seiler,Deborah Bell-Pedersen,John V. Paietta,Nora Plesofsky,Michael Plamann,Marta Goodrich-Tanrikulu,Ulrich Schulte,Gertrud Mannhaupt,Frank E. Nargang,Alan Radford,Claude P. Selitrennikoff,James E. Galagan,Jay C. Dunlap,Jennifer J. Loros,David E. A. Catcheside,Hirokazu Inoue,Rodolfo Aramayo,Michael Polymenis,Eric U. Selker,Matthew S. Sachs,George A. Marzluf,Ian T. Paulsen,Rowland H. Davis,Daniel J. Ebbole,Alex Zelter,Eric R. Kalkman,Rebecca O’Rourke,Frederick J. Bowring,Jane Yeadon,Chizu Ishii,Keiichiro Suzuki,Wataru Sakai,Robert Pratt +38 more
TL;DR: An analysis of over 1,100 of the ∼10,000 predicted proteins encoded by the genome sequence of the filamentous fungus Neurospora crassa reveals potential new targets for antifungals as well as loci implicated in human and plant physiology and disease.
Journal ArticleDOI
Polarisome Meets Spitzenkörper: Microscopy, Genetics, and Genomics Converge
Steven D. Harris,Nick D. Read,Robert W. Roberson,Brian D. Shaw,Stephan Seiler,Mike Plamann,Michelle Momany +6 more
TL;DR: The impact of filamentous fungi on human welfare has never been greater and they are attaining increasing notoriety for their ability to cause life-threatening infections in humans.
Journal ArticleDOI
De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis.
Minou Nowrousian,Jason E. Stajich,Meiling Chu,Ines Engh,Eric Espagne,Karen J. Halliday,Jens Kamerewerd,Frank Kempken,Birgit Knab,Hsiao-Che Kuo,Heinz D. Osiewacz,Stefanie Pöggeler,Nick D. Read,Stephan Seiler,Kristina M. Smith,Denise Zickler,Ulrich Kück,Michael Freitag +17 more
TL;DR: This study shows that, for typical filamentous fungi, de novo assembly of genomes from short sequence reads alone is feasible, that a mixture of Solexa and 454 sequencing substantially improves the assembly, and that the resulting data can be used for comparative studies to address basic questions of fungal biology.
Journal ArticleDOI
The genetic basis of cellular morphogenesis in the filamentous fungus Neurospora crassa.
Stephan Seiler,Michael Plamann +1 more
TL;DR: A large-scale genetic screen for the isolation of conditional mutants defective in this process in the model fungus Neurospora crassa is developed and a molecular model for studies of hyphal growth and polarity is established.