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Shunguang Wang
Researcher at Broad Institute
Publications - 4
Citations - 1976
Shunguang Wang is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome & Genome evolution. The author has an hindex of 3, co-authored 3 publications receiving 1906 citations. Previous affiliations of Shunguang Wang include Massachusetts Institute of Technology.
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Journal ArticleDOI
The genome sequence of the filamentous fungus Neurospora crassa
James E. Galagan,Sarah E. Calvo,Katherine A. Borkovich,Eric U. Selker,Nick O. Read,David B. Jaffe,William Fitzhugh,Li-Jun Ma,Serge Smirnov,Seth Purcell,Bushra Rehman,Timothy Elkins,Reinhard Engels,Shunguang Wang,Cydney B. Nielsen,Jonathan Butler,Matthew G. Endrizzi,Dayong Qui,Peter Ianakiev,Deborah Bell-Pedersen,Mary Anne Nelson,Margaret Werner-Washburne,Claude P. Selitrennikoff,John A. Kinsey,Edward L. Braun,Alex Zelter,Alex Zelter,Ulrich Schulte,Gregory O. Kothe,Gregory Jedd,Werner Mewes,Chuck Staben,Edward M. Marcotte,David Greenberg,Alice Roy,Karen Foley,Jerome Naylor,Nicole Stange-Thomann,Robert Barrett,Sante Gnerre,Michael Kamal,Manolis Kamvysselis,Evan Mauceli,Cord Bielke,Stephen Rudd,Dmitrij Frishman,Svetlana Krystofova,Carolyn G. Rasmussen,Robert L. Metzenberg,David D. Perkins,Scott Kroken,Carlo Cogoni,Giuseppe Macino,David E. A. Catcheside,Weixi Li,Robert J. Pratt,Stephen A. Osmani,Colin P.C. DeSouza,Louise Glass,Marc J. Orbach,J. Andrew Berglund,Rodger B. Voelker,Oded Yarden,Michael Plamann,Stephan Seiler,Jay C. Dunlap,Alan Radford,Rodolfo Aramayo,Donald O. Natvig,Lisa A. Alex,Gertrud Mannhaupt,Daniel J. Ebbole,Michael Freitag,Ian T. Paulsen,Matthew S. Sachs,Eric S. Lander,Chad Nusbaum,Bruce W. Birren +77 more
TL;DR: A high-quality draft sequence of the N. crassa genome is reported, suggesting that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.
Journal ArticleDOI
The Complete Genome and Proteome of Mycoplasma mobile
Jacob D. Jaffe,Nicole Stange-Thomann,Cherylyn Smith,David DeCaprio,Sheila Fisher,Jonathan Butler,Sarah E. Calvo,Tim Elkins,Michael Fitzgerald,Nabil Hafez,Chinnappa D. Kodira,John E. Major,Shunguang Wang,Jane E. Wilkinson,Robert Nicol,Chad Nusbaum,Bruce W. Birren,Howard C. Berg,George M. Church +18 more
TL;DR: For the first time, proteomic data are used in the primary annotation of a new genome, providing validation of expression for many of the predicted proteins, including a long repeating unit of DNA of approximately 2435 bp present in five complete copies.
Journal ArticleDOI
Analysis of the DNA sequence and duplication history of human chromosome 15
Michael C. Zody,Manuel Garber,Ted Sharpe,Sarah Young,Lee Rowen,Keith O'Neill,Charles A. Whittaker,Michael Kamal,Jean L. Chang,Christina A. Cuomo,Ken Dewar,Michael Fitzgerald,Chinnappa D. Kodira,Anup Madan,Shizhen Qin,Xiaoping Yang,Nissa Abbasi,Amr Abouelleil,Harindra Arachchi,Lida Baradarani,Brian Birditt,Scott Bloom,Toby Bloom,Mark L. Borowsky,Jeremy Burke,Jonathan Butler,April Cook,Kurt DeArellano,David DeCaprio,Lester Dorris,Monica Dors,Evan E. Eichler,Reinhard Engels,Jessica Fahey,Peter Fleetwood,Cynthia Friedman,Gary Gearin,Jennifer L. Hall,Grace Hensley,Ericka M. Johnson,Charlien Jones,Asha Kamat,Amardeep Kaur,Devin P. Locke,Anuradha Madan,Glen Munson,David B. Jaffe,Annie Lui,Pendexter Macdonald,Evan Mauceli,Jerome Naylor,Ryan Nesbitt,Robert Nicol,Sinéad B. O'Leary,Amber L Ratcliffe,Steven Rounsley,Xinwei She,Katherine M. B. Sneddon,Sandra Stewart,Carrie Sougnez,Sabrina M. Stone,Kerri Topham,Dascena Vincent,Shunguang Wang,Andrew Zimmer,Bruce W. Birren,Leroy Hood,Eric S. Lander,Chad Nusbaum +68 more
TL;DR: A detailed analysis of the duplication structure of human chromosome 15 finds that most of the intrachromosomal duplications seem to share a common ancestry, and demonstrates that some remaining gaps in the genome sequence are probably due to structural polymorphisms between haplotypes.
Journal ArticleDOI
Abstract CT503: A phase I/Ib study of the safety and preliminary efficacy of NZV930 alone and in combination with spartalizumab and/or taminadenant in patients (pts) with advanced malignancies
Siqing Fu,Udai Banerji,Philippe L. Bedard,Aitana Calvo Ferrándiz,Alberto Chiappori,Jayesh Desai,Rahima Jamal,Desamparados Roda Perez,H. Yamamoto,Erica Vieira,Gabrielle K.W. Wong,Kulandayan K. Subramanian,Shunguang Wang,Brittany Arianna Mueller,Javier Álvarez Otero,Si-Lin Koo +15 more
TL;DR: NZV930 SA and its combinations exhibited a tolerable safety profile in multiple advanced solid tumors and showed good PK properties, with target-mediated drug disposition at lower doses, which normalize to typical IgG-like PKs at higher doses.