A
Aurélie Couturier-Maillard
Researcher at University of Orléans
Publications - 15
Citations - 1777
Aurélie Couturier-Maillard is an academic researcher from University of Orléans. The author has contributed to research in topics: Inflammation & Inflammasome. The author has an hindex of 12, co-authored 14 publications receiving 1320 citations. Previous affiliations of Aurélie Couturier-Maillard include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands
Bruno Lamas,Mathias L. Richard,Valentin Leducq,Hang-Phuong Pham,Marie-Laure Michel,Grégory Da Costa,Chantal Bridonneau,Sarah Jegou,Thomas W. Hoffmann,Jane M. Natividad,Loic Brot,Soraya Taleb,Soraya Taleb,Aurélie Couturier-Maillard,Isabelle Nion-Larmurier,Fatiha Merabtene,Philippe Seksik,Anne Bourrier,Jacques Cosnes,Bernhard Ryffel,Bernhard Ryffel,Laurent Beaugerie,Jean-Marie Launay,Philippe Langella,Ramnik J. Xavier,Harry Sokol +25 more
TL;DR: In this article, a relationship between the host and the gut microbiota govern intestinal homeostasis is revealed, and the authors reveal that host genes affect the composition and function of the Gut microbiota, altering the production of microbial metabolites and intestinal inflammation.
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NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer
Aurélie Couturier-Maillard,Thomas Secher,Ateequr Rehman,Sylvain Normand,Adèle De Arcangelis,Robert Haesler,Ludovic Huot,Teddy Grandjean,Aude Bressenot,Anne Delanoye-Crespin,Olivier Gaillot,Stefan Schreiber,Yves Lemoine,Bernhard Ryffel,David Hot,Gabriel Núñez,Grace Y. Chen,Philip Rosenstiel,Mathias Chamaillard +18 more
TL;DR: It is shown that dysbiosis caused by Nod2 deficiency gives rise to a reversible, communicable risk of colitis and colitis-associated carcinogenesis in mice, and manipulation of dysbiotic microbiota is a potential therapeutic approach in the treatment of human intestinal disorders.
Journal ArticleDOI
Pseudomonas aeruginosa type-3 secretion system dampens host defense by exploiting the NLRC4-coupled inflammasome.
Emmanuel Faure,Jean-Baptiste Mear,Karine Faure,Sylvain Normand,Aurélie Couturier-Maillard,Teddy Grandjean,Viviane Balloy,Bernhard Ryffel,Rodrigue Dessein,Michel Chignard,Catherine Uyttenhove,Benoit Guery,Philippe Gosset,Mathias Chamaillard,Eric Kipnis +14 more
TL;DR: Through NLRC4 inflammasome activation, the T3SS promotes IL-18 secretion, which dampens a beneficial IL-17-mediated antimicrobial host response.
Journal ArticleDOI
Targeting the NLRP3 Inflammasome to Reduce Diet-Induced Metabolic Abnormalities in Mice.
Fausto Chiazza,Aurélie Couturier-Maillard,Elisa Benetti,Raffaella Mastrocola,Debora Nigro,Juan Carlos Cutrin,Juan Carlos Cutrin,Loredana Serpe,Manuela Aragno,Roberto Fantozzi,Bernard Ryffel,Christoph Thiemermann,Massimo Collino +12 more
TL;DR: Results demonstrate that the selective pharmacological modulation of the NLRP3 inflammasome attenuates the metabolic abnormalities and the related organ injury/dysfunction caused by chronic exposure to HD, with effects similar to those obtained byNLRP3 gene silencing.
Inflammasome, IL-1 and inflammation in ozone-induced lung injury.
Chloé Michaudel,Aurélie Couturier-Maillard,Pauline Chenuet,Isabelle Maillet,Catherine Mura,Isabelle Couillin,Aurélie Gombault,Valérie F. J. Quesniaux,François Huaux,Bernhard Ryffel +9 more
TL;DR: The present data suggest that ozone induced oxidative stress causes inflammasome activation with the release of IL-1, other cytokines and proteases driving lung inflammation leading to the destruction of alveolar epithelia with emphysema and respiratory failure.