J
Jacques Neefjes
Researcher at Leiden University Medical Center
Publications - 352
Citations - 34927
Jacques Neefjes is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: MHC class I & Antigen presentation. The author has an hindex of 95, co-authored 331 publications receiving 31500 citations. Previous affiliations of Jacques Neefjes include University of Amsterdam & Netherlands Cancer Institute.
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Journal ArticleDOI
HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading
S.M. van Ham,E. Tjin,Björn F. Lillemeier,Ulrike Gruneberg,K. E. Van Meijgaarden,L. Pastoors,Desiree Verwoerd,Abraham Tulp,Benito Cañas,Dinah Rahman,Tom H. M. Ottenhoff,Darryl J. Pappin,John Trowsdale,Jacques Neefjes +13 more
TL;DR: HLA-DO affects the peptide repertoire that is eventually presented to the immune system by MHC class II molecules, and is a negative modulator of HLA-DM.
Journal ArticleDOI
Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma
Tiziana Scanu,Robbert M. Spaapen,Jeroen Bakker,Chandra Bhan Pratap,Lin-en Wu,Ingrid Hofland,Annegien Broeks,Vijay K. Shukla,Mohan Kumar,Hans Janssen,Ji-Ying Song,E. Andra Neefjes-Borst,Hein te Riele,David W. Holden,Gopal Nath,Jacques Neefjes +15 more
TL;DR: It is indicated that Salmonella enterica can promote transformation of genetically predisposed cells and is a causative agent of GBC.
Journal ArticleDOI
Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1.
Inmaculada Hernández-Muñoz,Panthea Taghavi,Coenraad Kuijl,Jacques Neefjes,Maarten van Lohuizen +4 more
TL;DR: It is demonstrated that the maintenance DNA methyltransferase DNMT1 is necessary for proper PcG body assembly independent of DNMT-associated histone deacetylase activity and suggested a highly regulated recruitment of PRC1 to chromatin.
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Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L.
Rik van der Kant,Alexander Fish,Lennert Janssen,Hans Janssen,Sabine Krom,Nataschja Ho,Thijn R. Brummelkamp,Jan E. Carette,Nuno Rocha,Jacques Neefjes +9 more
TL;DR: It is described that lysosomal tethering and transport are combined processes co-regulated by one multi-protein complex: RAB7–RILP–ORP1L, which efficiently couples and regulates the timing of microtubule minus-end transport and fusion, two major events in endosomal biology.
Journal ArticleDOI
Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway
Ruud H. Wijdeven,Hans Janssen,Leila Nahidiazar,Lennert Janssen,Lennert Janssen,Kees Jalink,Ilana Berlin,Ilana Berlin,Jacques Neefjes,Jacques Neefjes +9 more
TL;DR: ORP1L, via its liganding by lipids and the formation of contacts between autophagic vacuoles and the ER, governs the last steps in autophagy that lead to the lysosomal degradation of cytosolic material.