J
Jacques Neefjes
Researcher at Leiden University Medical Center
Publications - 352
Citations - 34927
Jacques Neefjes is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: MHC class I & Antigen presentation. The author has an hindex of 95, co-authored 331 publications receiving 31500 citations. Previous affiliations of Jacques Neefjes include University of Amsterdam & Netherlands Cancer Institute.
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Journal ArticleDOI
Regulation of MHC class II antigen presentation by sorting of recycling HLA-DM/DO and class II within the multivesicular body.
M. van Lith,M. van Ham,Alexander Griekspoor,E. Tjin,Desiree Verwoerd,Jero Calafat,Hans Janssen,Eric Reits,L. Pastoors,Jacques Neefjes +9 more
TL;DR: It is shown that DM/DO complexes continuously recycle between the plasma membrane and the lysosomal MIICs, which augments the efficiency of class II antigenic peptide loading by affecting the efficacy of lateral interaction betweenDM/DO and class II molecules.
Journal ArticleDOI
HFE cross-talks with the MHC class I antigen presentation pathway
Sérgio F. de Almeida,Sérgio F. de Almeida,Isabel F. Carvalho,Isabel F. Carvalho,Carla Cardoso,Carla Cardoso,João V. Cordeiro,João V. Cordeiro,Jorge E. Azevedo,Jorge E. Azevedo,Jacques Neefjes,Jacques Neefjes,Maria de Sousa,Maria de Sousa +13 more
TL;DR: The present results suggest the existence of an intriguing cross-talk between a particular HFE mutation and the classical MHC class I route and provide additional evidence for the occurrence of immunologic defects in patients with HH.
Journal ArticleDOI
Genome-wide identification and characterization of novel factors conferring resistance to topoisomerase II poisons in cancer
Ruud H. Wijdeven,Baoxu Pang,Sabina Y van der Zanden,Xiaohang Qiao,Vincent A. Blomen,Marlous Hoogstraat,Esther H. Lips,Lennert Janssen,Lodewyk F. A. Wessels,Thijn R. Brummelkamp,Jacques Neefjes +10 more
TL;DR: This work identifies genes that may predict the response of cancer patients to the broadly used topoisomerase II poisons and defines alternative pathways that could be therapeutically exploited in treatment-resistant patients.
Journal ArticleDOI
Definition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules.
Celia R. Berkers,Annemieke de Jong,Karianne Schuurman,Carsten Linnemann,Hugo D. Meiring,Lennert Janssen,Jacques Neefjes,Ton N. Schumacher,Boris Rodenko,Huib Ovaa +9 more
TL;DR: It is observed that splicing does not occur at random, neither in terms of the amino acid sequences nor through random splicing of peptides from different sources, and splicing followed distinct rules that were deduced and validated both in vitro and in cells.
Journal Article
Association with beta 2-microglobulin controls the expression of transfected human class I genes.
TL;DR: Introduction of a human beta 2-microglobulin gene into L cells transfected with the HLA-B27 gene rescued the expression of HLA -B27 at the cell surface, as evidenced by reactivity with W6/32, surface staining, and the presence of sialic acid on the heavy chain.