J
Jacques Neefjes
Researcher at Leiden University Medical Center
Publications - 352
Citations - 34927
Jacques Neefjes is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: MHC class I & Antigen presentation. The author has an hindex of 95, co-authored 331 publications receiving 31500 citations. Previous affiliations of Jacques Neefjes include University of Amsterdam & Netherlands Cancer Institute.
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Journal ArticleDOI
Stop or Go? Endosome Positioning in the Establishment of Compartment Architecture, Dynamics, and Function
TL;DR: The latest advances in the understanding of the mechanisms underpinning endosomal transport and positioning are reviewed, with emphasis on the contributions from the ER and a perspective on how the interplay between these aspects shapes the architecture and dynamics of the endosome system and drives its myriad cellular functions.
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Ubiquitination by the Membrane-associated RING-CH-8 (MARCH-8) Ligase Controls Steady-state Cell Surface Expression of Tumor Necrosis Factor-related Apoptosis Inducing Ligand (TRAIL) Receptor 1
Bert van de Kooij,Inge Verbrugge,Evert de Vries,Merel Gijsen,Veronica Montserrat,C Maas,Jacques Neefjes,Jannie Borst +7 more
TL;DR: It is demonstrated that TRAIL-R1 is down-regulated from the cell surface, with great preference over TRAil-R2, by exogenous expression of MARCH ligases that are implicated in endosomal trafficking, such as MARCH-1 and -8.
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On the move: organelle dynamics during mitosis
TL;DR: Current understanding of intracellular organelle segregation during mitotic division in mammalian cells is reviewed, with a focus on compartment organization and integrity throughout the inheritance process.
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MHC class I alleles and their exploration of the antigen-processing machinery.
TL;DR: This work introduces the players in the antigen processing and presentation cascade and describes their specificity and allelic variation, and highlights MHC class I alleles, which are not only different in sequence but also use different aspects of the antigen presentation pathway to their advantage.
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Uncoupling DNA damage from chromatin damage to detoxify doxorubicin.
Xiaohang Qiao,Sabina Y van der Zanden,Dennis P A Wander,Daniel M. Borràs,J.-Y. Song,Xiao Yang Li,Suzanne van Duikeren,Noortje van Gils,Arjo Rutten,Tessa van Herwaarden,Olaf van Tellingen,Elisa Giacomelli,Milena Bellin,Valeria V. Orlova,Leon G.J. Tertoolen,Sophie Gerhardt,Jimmy J. Akkermans,Jeroen Bakker,Charlotte L. Zuur,Baoxu Pang,Anke M. Smits,Christine L. Mummery,Linda Smit,Ramon Arens,Junmin Li,Hermen S. Overkleeft,Jacques Neefjes +26 more
TL;DR: The results suggest that anthracycline variants acting primarily via chromatin damage may allow prolonged treatment of cancer patients and will improve the quality of life of cancer survivors.