J
Jacques Neefjes
Researcher at Leiden University Medical Center
Publications - 352
Citations - 34927
Jacques Neefjes is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: MHC class I & Antigen presentation. The author has an hindex of 95, co-authored 331 publications receiving 31500 citations. Previous affiliations of Jacques Neefjes include University of Amsterdam & Netherlands Cancer Institute.
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Journal ArticleDOI
Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs.
Birol Cabukusta,Ilana Berlin,Daphne M. van Elsland,Iris Forkink,Menno Spits,Anja W.M. de Jong,Jimmy J. Akkermans,Ruud H. Wijdeven,George M.C. Janssen,Peter A. van Veelen,Jacques Neefjes +10 more
TL;DR: MOSPD1 and MOSPD3 are described as ER-localized tethers interacting with FFAT motif-containing proteins that expand the VAP family of proteins and highlight two separate complexes in control of interactions between intracellular compartments.
Journal ArticleDOI
PKA phosphorylation redirects ERα to promoters of a unique gene set to induce tamoxifen resistance.
R de Leeuw,Koen D. Flach,C Bentin Toaldo,Xanthippi Alexi,Sander Canisius,Jacques Neefjes,Rob Michalides,Wilbert Zwart +7 more
TL;DR: It is demonstrated that activation of the PKA signaling pathway alters the transcriptome by redirecting ERα to new transcriptional start sites, resulting in altered transcription and TAM resistance.
Journal ArticleDOI
Cutting Edge: HLA-B27 Acquires Many N-Terminal Dibasic Peptides: Coupling Cytosolic Peptide Stability to Antigen Presentation
Carla A. Herberts,Joost Neijssen,Jolanda de Haan,Lennert Janssen,Jan W. Drijfhout,Eric Reits,Jacques Neefjes +6 more
TL;DR: It is suggested that HLA-B27 can present peptides from Ags present in fewer copies than required for successful peptide generation for other MHC class I molecules.
Journal ArticleDOI
Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm
Nobuhito Ono,Ingrid van der Heijden,George L. Scheffer,Koen van de Wetering,Elizabeth Van Deemter,Marcel de Haas,Arjan Boerke,Bart M. Gadella,Dirk G. de Rooij,Dirk G. de Rooij,Jacques Neefjes,Tom A.M. Groothuis,L. C. J. M. Oomen,Lenny Brocks,Toshihisa Ishikawa,Piet Borst +15 more
TL;DR: In mouse and boar sperm, Mrp9 localizes to the midpiece, a structure containing all sperm mitochondria, however, immunolocalization microscopy and cell fractionation studies with transfected HEK-293 cells and mouse testis show that MRP9/Mrp9 does not localize to mitochondria.
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Drug Discovery Maps, a Machine Learning Model That Visualizes and Predicts Kinome–Inhibitor Interaction Landscapes
Antonius P A Janssen,Sebastian H. Grimm,Ruud H. Wijdeven,Eelke B. Lenselink,Jacques Neefjes,Constant A. A. van Boeckel,Gerard J. P. van Westen,Mario van der Stelt +7 more
TL;DR: Drug Discovery Maps (DDM) is a machine learning model that maps the activity profile of compounds across an entire protein family, based on the t-distributed stochastic neighbor embedding algorithm to generate a visualization of molecular and biological similarity.