Jakob Wirbel

TL;DR: A meta-analysis of eight geographically and technically diverse fecal shotgun metagenomic studies of colorectal cancer identified a core set of 29 species significantly enriched in CRC metagenomes, establishing globally generalizable, predictive taxonomic and functional microbiome CRC signatures as a basis for future diagnostics.

TL;DR: The combined analysis of heterogeneous CRC cohorts identified reproducible microbiome biomarkers and accurate disease-predictive models that can form the basis for clinical prognostic tests and hypothesis-driven mechanistic studies.

TL;DR: Evidence is found for a vast majority of oral species to be transferable, with increased levels of transmission in colorectal cancer and rheumatoid arthritis patients and, more generally, for species described as opportunistic pathogens.

TL;DR: In this article, the authors characterized 144 antibiotics from a previous screen of more than 1,000 drugs on 38 representative human gut microbiome species and identified drugs that mitigate their collateral damage on commensal bacteria without compromising their efficacy against pathogens.

TL;DR: In this paper, the authors developed SIAMCAT, a toolbox for ML-based comparative metagenomics, which demonstrated its capabilities in a meta-analysis of fecal metagenomic studies (10,803 samples).