J
James Ansara
Researcher at Boston Children's Hospital
Publications - 3
Citations - 960
James Ansara is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Cytotoxic T cell & GNLY. The author has an hindex of 3, co-authored 3 publications receiving 336 citations. Previous affiliations of James Ansara include Harvard University.
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Journal ArticleDOI
Gasdermin E suppresses tumour growth by activating anti-tumour immunity.
Zhibin Zhang,Zhibin Zhang,Ying Zhang,Ying Zhang,Shiyu Xia,Shiyu Xia,Qing Kong,Shunying Li,Xing Liu,Xing Liu,Xing Liu,Caroline Junqueira,Caroline Junqueira,Caroline Junqueira,Karla F. Meza-Sosa,Karla F. Meza-Sosa,Karla F. Meza-Sosa,Temy Mo Yin Mok,Temy Mo Yin Mok,Temy Mo Yin Mok,James Ansara,James Ansara,Satyaki Sengupta,Yandan Yao,Hao Wu,Hao Wu,Judy Lieberman,Judy Lieberman +27 more
TL;DR: The gasdermin E protein is shown to act as a tumour suppressor: it is cleaved by caspase 3 and granzyme B and leads to pyroptosis of cancer cells, provoking an immune response to the tumour.
Journal ArticleDOI
Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites
Farokh Dotiwala,Sachin Mulik,Sachin Mulik,Rafael B. Polidoro,Rafael B. Polidoro,Rafael B. Polidoro,James Ansara,Barbara A. Burleigh,Michael Walch,Ricardo T. Gazzinelli,Judy Lieberman,Judy Lieberman +11 more
TL;DR: GNLY-transgenic mice are protected against infection by T. cruzi and T. gondii, and survive infections that are lethal to wild-type mice, and GNLY, PFN- and Gzm-mediated elimination of intracellular protozoan parasites is an unappreciated immune defense mechanism.
Journal ArticleDOI
Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts
Ângela C. Crespo,Ângela C. Crespo,Ângela C. Crespo,Sachin Mulik,Farokh Dotiwala,James Ansara,Sumit Sen Santara,Kayleigh Ingersoll,Cristian Ovies,Caroline Junqueira,Caroline Junqueira,Tamara Tilburgs,Jack L. Strominger,Judy Lieberman +13 more
TL;DR: It is shown that human dNK cells highly express the antimicrobial peptide granulysin (GNLY) and selectively transfer it via nanotubes to extravillous trophoblasts to kill intracellular Listeria monocytogenes (Lm) without killing the trophoblast.