J
James J.H. Chong
Researcher at University of Sydney
Publications - 72
Citations - 2868
James J.H. Chong is an academic researcher from University of Sydney. The author has contributed to research in topics: Medicine & Stem cell. The author has an hindex of 16, co-authored 57 publications receiving 2351 citations. Previous affiliations of James J.H. Chong include Westmead Hospital & Millennium Institute.
Papers
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Journal ArticleDOI
Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts
James J.H. Chong,Xiulan Yang,Creighton W. Don,Elina Minami,Yen-Wen Liu,Jill J. Weyers,William M. Mahoney,Benjamin Van Biber,Savannah Cook,Nathan J. Palpant,Jay Gantz,James A. Fugate,Veronica Muskheli,G. Michael Gough,Keith W. Vogel,Cliff A. Astley,Charlotte E. Hotchkiss,Audrey Baldessari,Lil Pabon,Hans Reinecke,Edward A. Gill,Veronica Nelson,Hans-Peter Kiem,Hans-Peter Kiem,Michael A. Laflamme,Charles E. Murry +25 more
TL;DR: It is shown that hESC-CMs can be produced at a clinical scale (more than one billion cells per batch) and cryopreserved with good viability and can remuscularize substantial amounts of the infarcted monkey heart.
Journal ArticleDOI
Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin
James J.H. Chong,Vashe Chandrakanthan,Vashe Chandrakanthan,Munira Xaymardan,Munira Xaymardan,Munira Xaymardan,Naisana S. Asli,Joan Li,Ishtiaq Ahmed,Corey Heffernan,Mary K. Menon,Christopher J. Scarlett,Christopher J. Scarlett,Amirsalar Rashidianfar,Christine Biben,Christine Biben,Hans Zoellner,Emily K. Colvin,John E. Pimanda,Andrew V. Biankin,Bin Zhou,William T. Pu,Owen W.J. Prall,Owen W.J. Prall,Richard P. Harvey,Richard P. Harvey,Richard P. Harvey +26 more
TL;DR: A population of adult cardiac-resident CFU-Fs (cCFU-F) that occupy a perivascular, adventitial niche and show broad trans-germ layer potency in vitro and in vivo are described.
Journal ArticleDOI
Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia.
Jose Perdomo,Halina H.L. Leung,Zohra Ahmadi,Feng Yan,James J.H. Chong,Freda Passam,Beng H. Chong +6 more
TL;DR: Neutrophil activation and NETosis are elevated in patients with HIT, and are essential for thrombosis in HIT mouse models, and may lead to new therapeutic strategies.
Journal ArticleDOI
Heparin-induced thrombocytopenia
Beng H. Chong,James J.H. Chong +1 more
TL;DR: The frequency, pathophysiology, clinical features, diagnosis and management of HIT, commonly termed Type II heparin-induced thrombocytopenia (HIT), is discussed.
Journal ArticleDOI
Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart.
James J.H. Chong,Hans Reinecke,Mineo Iwata,Beverly Torok-Storb,April Stempien-Otero,Charles E. Murry +5 more
TL;DR: Data suggest that a subfraction of the cardiac PDGFRα+ populations are progenitors contributing predominantly to the vascular and mesenchymal compartments of the human heart.