MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion
Christopher J. Oliphant,You Yi Hwang,Jennifer A. Walker,Maryam Salimi,See Heng Wong,James M. Brewer,Alexandros Englezakis,Jillian L. Barlow,Emily Hams,Seth T. Scanlon,Graham S. Ogg,Padraic G. Fallon,Padraic G. Fallon,Andrew N J McKenzie +13 more
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TLDR
During transition to adaptive T cell-mediated immunity, the ILC2 and T cell crosstalk contributes to their mutual maintenance, expansion and cytokine production and identifies a previously unappreciated pathway in the regulation of type-2 immunity.About:
This article is published in Immunity.The article was published on 2014-08-21 and is currently open access. It has received 583 citations till now. The article focuses on the topics: Innate lymphoid cell & Immunity.read more
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The biology of innate lymphoid cells
David Artis,Hergen Spits +1 more
TL;DR: This work summarizes the studies that formally identified innate lymphoid cells and highlights their emerging roles in controlling tissue homeostasis in the context of infection, chronic inflammation, metabolic disease and cancer.
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The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
TL;DR: Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.
Journal ArticleDOI
Innate Lymphoid Cells: 10 Years On.
Eric Vivier,David Artis,Marco Colonna,Andreas Diefenbach,James P. Di Santo,James P. Di Santo,Gérard Eberl,Gérard Eberl,Shigeo Koyasu,Richard M. Locksley,Andrew N. J. McKenzie,Reina E. Mebius,Fiona Powrie,Hergen Spits +13 more
TL;DR: The advances in ILC biology over the past decade are distill the advances to refine the nomenclature of ILCs and highlight the importance of I LCs in tissue homeostasis, morphogenesis, metabolism, repair, and regeneration.
Journal ArticleDOI
Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit
TL;DR: It is shown that tuft cells constitutively express IL-25 to sustain ILC2 homeostasis in the resting lamina propria in mice, and comprise a response circuit that mediates epithelial remodelling associated with type 2 immunity in the small intestine, and perhaps at other mucosal barriers populated by these cells.
References
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Journal ArticleDOI
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Daniel R. Neill,See Heng Wong,Agustin Bellosi,Robin J. Flynn,Maria Daly,Theresa K. A. Langford,Christine Bucks,Colleen M. Kane,Padraic G. Fallon,Richard Pannell,Helen E. Jolin,Andrew N.J. McKenzie +11 more
TL;DR: The identification and functional characterization of a new innate type-2 immune effector leukocyte that is named the nuocyte is presented, which represents a critically important innate effector cell in type- 2 immunity.
Journal ArticleDOI
Innate production of T H 2 cytokines by adipose tissue-associated c-Kit + Sca-1 + lymphoid cells
Kazuyo Moro,Taketo Yamada,Masanobu Tanabe,Tsutomu Takeuchi,Tomokatsu Ikawa,Hiroshi Kawamoto,Jun Ichi Furusawa,Masashi Ohtani,Hideki Fujii,Shigeo Koyasu +9 more
TL;DR: In this article, a new type of innate lymphocyte present in a novel lymphoid structure associated with adipose tissues in the peritoneal cavity was reported. But these cells do not express lineage (Lin) markers but do express c-Kit, Sca-1 (also known as Ly6a), IL7R and IL33R.
Journal ArticleDOI
Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements
TL;DR: Results show that successful generation of MHC class II‐restricted, OVA‐specific αβTCR transgenic mice was dependent upon combining cDNA‐ and genomic DNA‐based constructs for expression of the respective α‐ and β‐chains of the TCR.
Journal ArticleDOI
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Laurel A. Monticelli,Gregory F. Sonnenberg,Michael C. Abt,Theresa Alenghat,Carly G. K. Ziegler,Travis A. Doering,Jill M. Angelosanto,Brian J. Laidlaw,Cliff Y Yang,Taheri Sathaliyawala,Masaru Kubota,Damian Turner,Joshua M. Diamond,Ananda W. Goldrath,Donna L. Farber,Ronald G. Collman,E. John Wherry,David Artis +17 more
TL;DR: A critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after infection with influenza virus is demonstrated.
Journal ArticleDOI
Disruption of the murine IL-4 gene blocks Th2 cytokine responses
Manfred Kopf,G. Le Gros,Martin F. Bachmann,Marinus C. Lamers,Horst Bluethmann,Georges Köhler +5 more
TL;DR: It is concluded that IL-4 is required for the generation of the Th2-derived cytokines and that immune responses dependent on these cytokines are impaired.
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Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Laurel A. Monticelli,Gregory F. Sonnenberg,Michael C. Abt,Theresa Alenghat,Carly G. K. Ziegler,Travis A. Doering,Jill M. Angelosanto,Brian J. Laidlaw,Cliff Y Yang,Taheri Sathaliyawala,Masaru Kubota,Damian Turner,Joshua M. Diamond,Ananda W. Goldrath,Donna L. Farber,Ronald G. Collman,E. John Wherry,David Artis +17 more