J
James M. Musser
Researcher at Houston Methodist Hospital
Publications - 477
Citations - 44674
James M. Musser is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Streptococcus pyogenes & Virulence. The author has an hindex of 113, co-authored 461 publications receiving 42030 citations. Previous affiliations of James M. Musser include Rocky Mountain Laboratories & Baylor College of Medicine.
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Journal ArticleDOI
Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics
Robert K. Selander,Dominique A. Caugant,Howard Ochman,James M. Musser,Marion N. Gilmour,Thomas S. Whittam +5 more
TL;DR: Methodes d'extraction d'enzymes, d'electrophorese en gel and de coloration specifique des enzymes utilisees pour etudier la variation genetique chez Escherichia coli et d'autres bacteries.
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Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update.
TL;DR: Although remarkable advances have been made, much remains to be learned about the molecular genetic basis of drug resistance in Mycobacterium tuberculosis, it is reasonable to believe that development of new therapeutics based on knowledge obtained from the study of the molecular mechanisms of resistance will occur.
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STAT3 Mutations in the Hyper-IgE Syndrome
Steven M. Holland,Frank R. DeLeo,Houda Elloumi,Amy P. Hsu,Gulbu Uzel,Nina N. Brodsky,Alexandra F. Freeman,Andrew P. Demidowich,Joie Davis,Maria L. Turner,Victoria L. Anderson,Dirk Darnell,Pamela Welch,Douglas B. Kuhns,David M. Frucht,Harry L. Malech,John I. Gallin,Scott D. Kobayashi,Adeline R. Whitney,Jovanka M. Voyich,James M. Musser,Cristina Woellner,Alejandro A. Schäffer,Jennifer M. Puck,Bodo Grimbacher +24 more
TL;DR: Mutations in STAT3 underlie sporadic and dominant forms of the hyper-IgE syndrome, an immunodeficiency syndrome involving increased innate immune response, recurrent infections, and complex somatic features.
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Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination
Srinand Sreevatsan,Xi Pan,Kathryn E. Stockbauer,Nancy D. Connell,Barry N. Kreiswirth,Thomas S. Whittam,James M. Musser +6 more
TL;DR: Sequence analysis of two megabases in 26 structural genes or loci in strains recovered globally discovered a striking reduction of silent nucleotide substitutions compared with other human bacterial pathogens, indicating that M. tuberculosis is evolutionarily young and has recently spread globally.
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Antimicrobial agent resistance in mycobacteria: molecular genetic insights.
TL;DR: Molecular strategies show considerable promise for rapid detection of mutations associated with antimicrobial resistance and are now amenable to utilization in an appropriately equipped clinical microbiology laboratory.