Showing papers in "Tubercle and Lung Disease in 1998"

TL;DR: Although remarkable advances have been made, much remains to be learned about the molecular genetic basis of drug resistance in Mycobacterium tuberculosis, it is reasonable to believe that development of new therapeutics based on knowledge obtained from the study of the molecular mechanisms of resistance will occur.

TL;DR: Genetic susceptibility to tuberculosis among Gambians may be partly determined by genes in the IL1 gene cluster on chromosome 2, according to a study of tuberculosis cases and healthy blood donor controls.

TL;DR: It was surprising that all three strains of in vitro selected PZA resistant mutants were PZase-positive and showed no change in the pncA gene, indicating that additional mechanisms may be involved in PZA resistance.

TL;DR: Unexpectedly, it is found that IS6110 integrated at least 10 independent times between the dnaA and dnaN genes encoding deoxyribonucleic acid replication proteins.

TL;DR: The hypoxically induced nitrate reduction probably serves a respiratory function in supporting hypoxic shiftdown of M. tuberculosis from aerobic growth to non-replication persistence and represents a useful new marker for monitoring that shiftdown.

TL;DR: Galactofuranose biosynthesis can now be pursued as a potential drug target in M. tuberculosis.

TL;DR: In this paper, the molecular genetics of MDR-TB strains recovered in a Latin American country were investigated, and the types of drug resistanceassociated mutations identified were very similar to changes occurring in isolates from other areas of the world.

TL;DR: This work describes the complete 52,797 bp genome sequence of TM4 and a map of its genome organization and encodes several proteins with sequence similarity to those of other bacteriophages--including L5 and D29--indicating that they have common ancestry.

TL;DR: The recombinant HLPMt protein elicited a vigorous lymphoproliferative response especially in healthy tuberculin reactors compared to non-reactors and patients of tuberculosis, (P < 0.05).

TL;DR: This study indicates the importance of palaeopathology in identifying sometimes subtle lesions that may not be noted by clinicians because of their non-visibility on radiographs.

TL;DR: A separate lineage for the high copy and the low copy strains, and a possible sequential insertion of IS6110 in strains of M. tuberculosis with less than seven copies is suggested.

TL;DR: Although the mode of action of some of the agents with an anti-mycobacterial spectrum is not fully understood, it is evident that the restricted spectrum is likely to arise from the possession of unique targets, or specific pro-drug conversion systems, or to a combination of both mechanisms.

TL;DR: Data suggest that IdeR is a regulator of the cellular stress response, as it has a protective role in cells facing environmental stresses, such as increased levels of reactive oxygen species and INH toxic intermediates.

TL;DR: It is suggested that resident alveolar macrophages suppress lymphocyte proliferation in the guinea pig, but that the effect is not mediated by NO, PGE2 or H2O2.

TL;DR: The major mycobacterial iron regulator IdeR is identified and characterized that blocks the synthesis of the iron uptake machinery and has identified target genes in M. smegmatis and M. tuberculosis that are directly repressed by IdeR.

TL;DR: The in vitro activities of selected agents against Escherichia coli, Bacillus subtilis and Staphylococcus aureus were determined and demonstrated activity against some of the organisms suggesting that the targets of these drugs may not be restricted to mycobacterial species.

TL;DR: A two-component system of Mycobacterium tuberculosis H37Rv, designated as devR-devS, was identified in the laboratory, that encodes a response regulator and a histidine sensor-kinase respectively point towards variations in genomic organization and in transcriptional activity of virulent strains of M. tuberculosis.

TL;DR: A hitherto undescribed 100 kDa antigen, which shows a high degree of homology to ClpB, a member of the Clp family of proteases and was immunologically reactive with the rabbit hyperimmune serum against M. bovis BCG, is a previously unrecognized target of the human immune response to mycobacteria.