Journal ArticleDOI
Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update.
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TLDR
Although remarkable advances have been made, much remains to be learned about the molecular genetic basis of drug resistance in Mycobacterium tuberculosis, it is reasonable to believe that development of new therapeutics based on knowledge obtained from the study of the molecular mechanisms of resistance will occur.About:
This article is published in Tubercle and Lung Disease.The article was published on 1998-01-01. It has received 1136 citations till now. The article focuses on the topics: Resistance mutation & Gene mutation.read more
Citations
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Diversity of structures and properties among catalases.
TL;DR: Biochemical and physiological characterization of catalases from many different organisms has revealed a surprisingly wide range ofCatalatic efficiencies, despite similar sequences.
Journal ArticleDOI
Structural Mechanism for Rifampicin Inhibition of Bacterial RNA Polymerase
Elizabeth A. Campbell,Nataliya Korzheva,Arkady Mustaev,Katsuhiko S. Murakami,Satish K. Nair,Alex Goldfarb,Seth A. Darst +6 more
TL;DR: The crystal structure of Thermus aquaticus core RNAP complexed with Rif explains the effects of Rif on RNAP function and indicates that the inhibitor acts by directly blocking the path of the elongating RNA when the transcript becomes 2 to 3 nt in length.
Journal ArticleDOI
Efflux-Mediated Drug Resistance in Bacteria
Xian-Zhi Li,Hiroshi Nikaido +1 more
TL;DR: Fluoroquinolones and β-lactams of the latest generations are likely to select for overproduction mutants of these pumps and make the bacteria resistant in one step to practically all classes of antibacterial agents.
Journal ArticleDOI
Antimicrobial resistance in developing countries.
TL;DR: Better access to diagnostic laboratories is needed, as well as improved surveillance of the emergence of resistance, better regulation of antibiotics' use, and better education of the public, physicians, and veterinarians in the appropriate use of drugs.
Journal ArticleDOI
Whole-Genome Comparison of Mycobacterium tuberculosis Clinical and Laboratory Strains
Robert D. Fleischmann,David Alland,Jonathan A. Eisen,L. Carpenter,Owen White,Jeremy Peterson,Robert T. DeBoy,Robert J. Dodson,Michelle L. Gwinn,Daniel H. Haft,Erin Hickey,James F. Kolonay,William C. Nelson,Lowell Umayam,Maria D. Ermolaeva,Steven L. Salzberg,Arthur L. Delcher,T. Utterback,Janice Weidman,Hoda Khouri,John Gill,A. Mikula,William R. Bishai,William R. Jacobs,J. C. Venter,Claire M. Fraser +25 more
TL;DR: Results demonstrate that polymorphisms among M. tuberculosis strains are more extensive than initially anticipated, and genetic variation may have an important role in disease pathogenesis and immunity.
References
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Journal ArticleDOI
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Stewart T. Cole,Roland Brosch,Julian Parkhill,Thierry Garnier,Carol Churcher,David Harris,Stephen V. Gordon,Karin Eiglmeier,S. Gas,Clifton E. Barry,Fredj Tekaia,K. Badcock,D. Basham,D. Brown,Tracey Chillingworth,R. Connor,Robert L. Davies,K. Devlin,Theresa Feltwell,S. Gentles,N. Hamlin,S. Holroyd,T. Hornsby,Kay Jagels,Anders Krogh,J. McLean,Sharon Moule,Lee Murphy,K. Oliver,J. Osborne,Michael A. Quail,Marie-Adèle Rajandream,Jane Rogers,S. Rutter,K. Seeger,Jason Skelton,Rob Squares,S. Squares,John Sulston,K. Taylor,Sally Whitehead,Bart Barrell +41 more
TL;DR: The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve the understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions.
Journal ArticleDOI
Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms
Martin C. J. Maiden,Jane A. Bygraves,Edward J. Feil,Giovanna Morelli,Joanne E. Russell,Rachel Urwin,Qing Zhang,Jiaji Zhou,Kerstin Zurth,Dominique A. Caugant,Ian M. Feavers,Mark Achtman,Brian G. Spratt +12 more
TL;DR: Multilocus sequence typing (MLST), which exploits the unambiguous nature and electronic portability of nucleotide sequence data for the characterization of microorganisms, can be applied to almost all bacterial species and other haploid organisms, including those that are difficult to cultivate.
Journal ArticleDOI
Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemic.
TL;DR: The human immunodeficiency virus epidemic is causing increases in the number of tuberculosis cases, particularly in Africa, although increases are also expected in Southeast Asia.
Journal ArticleDOI
Tuberculosis: commentary on a reemergent killer.
TL;DR: The economic costs of not adequately addressing the problem of tuberculosis in this country are estimated from an epidemiological model.
Journal ArticleDOI
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
Asesh Banerjee,E. Dubnau,Annaik Quemard,V. Balasubramanian,Kyung Sun Um,T. Wilson,Desmond M. Collins,G.W. de Lisle,William R. Jacobs +8 more
TL;DR: Results suggest that InhA is likely a primary target of action for INH and ETH and that it may be involved in mycolic acid biosynthesis.
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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Stewart T. Cole,Roland Brosch,Julian Parkhill,Thierry Garnier,Carol Churcher,David Harris,Stephen V. Gordon,Karin Eiglmeier,S. Gas,Clifton E. Barry,Fredj Tekaia,K. Badcock,D. Basham,D. Brown,Tracey Chillingworth,R. Connor,Robert L. Davies,K. Devlin,Theresa Feltwell,S. Gentles,N. Hamlin,S. Holroyd,T. Hornsby,Kay Jagels,Anders Krogh,J. McLean,Sharon Moule,Lee Murphy,K. Oliver,J. Osborne,Michael A. Quail,Marie-Adèle Rajandream,Jane Rogers,S. Rutter,K. Seeger,Jason Skelton,Rob Squares,S. Squares,John Sulston,K. Taylor,Sally Whitehead,Bart Barrell +41 more