J
James P. Butler
Researcher at Harvard University
Publications - 324
Citations - 26460
James P. Butler is an academic researcher from Harvard University. The author has contributed to research in topics: Lung volumes & Obstructive sleep apnea. The author has an hindex of 74, co-authored 321 publications receiving 24090 citations. Previous affiliations of James P. Butler include Tohoku University & Brigham and Women's Hospital.
Papers
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Journal ArticleDOI
Low intensity ultrasound perturbs cytoskeleton dynamics
Natalya Mizrahi,Natalya Mizrahi,Enhua H. Zhou,Guillaume Lenormand,Ramaswamy Krishnan,Daphne Weihs,James P. Butler,David A. Weitz,Jeffrey J. Fredberg,Eitan Kimmel +9 more
TL;DR: In this paper, the authors report prompt fluidization of a cell and dramatic acceleration of its remodeling dynamics when exposed to low-intensity ultrasound, which is reminiscent of rejuvenation and aging phenomena that are well-established in certain soft inert materials.
Journal ArticleDOI
Regional rheological differences in locomoting neutrophils.
TL;DR: The significantly more fluidlike behavior of the leading edge supports the idea that intracellular pressure may be the origin of motive force in neutrophil locomotion, and structural damping well describes intrACEllular rheology.
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Biomechanical effects of environmental and engineered particles on human airway smooth muscle cells
Peter Berntsen,Chan Young Park,Barbara Rothen-Rutishauser,Akira Tsuda,T. M. Sager,Ramon M. Molina,Thomas C. Donaghey,Adriano M. Alencar,David I. Kasahara,Thomas Ericsson,Emil Millet,Jan Swenson,Daniel J. Tschumperlin,James P. Butler,Joseph D. Brain,Jeffrey J. Fredberg,Peter Gehr,Enhua H. Zhou +17 more
TL;DR: The results highlight the susceptibility of cellular mechanical function to particulate exposures and suggest that direct exposure of the airway smooth muscle cells to particulates may initiate or aggravate respiratory diseases.
Journal ArticleDOI
Transpulmonary pressures and lung mechanics with glossopharyngeal insufflation and exsufflation beyond normal lung volumes in competitive breath-hold divers.
Stephen H. Loring,Carl R. O'Donnell,James P. Butler,Peter Lindholm,Francine L. Jacobson,Massimo Ferrigno +5 more
TL;DR: It is concluded that the lungs of some healthy individuals are able to withstand repeated inflation to transpulmonary pressures far greater than those to which they would normally be exposed.
Journal ArticleDOI
Mechanosensing of substrate thickness
Yu-chun Lin,Dhananjay T. Tambe,Chan Young Park,Michael R. Wasserman,Xavier Trepat,Ramaswamy Krishnan,Guillaume Lenormand,Jeffrey J. Fredberg,James P. Butler +8 more
TL;DR: It is concluded that mechanosensing of substrate thickness is dominated in large part by traction forces spread over the lateral dimension of the cell, which is influenced greatly by intrinsic substrate stiffness but to a negligible extent by substrate thickness.