J
James P. Butler
Researcher at Harvard University
Publications - 324
Citations - 26460
James P. Butler is an academic researcher from Harvard University. The author has contributed to research in topics: Lung volumes & Obstructive sleep apnea. The author has an hindex of 74, co-authored 321 publications receiving 24090 citations. Previous affiliations of James P. Butler include Tohoku University & Brigham and Women's Hospital.
Papers
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Journal ArticleDOI
Airway geometry by analysis of acoustic pulse response measurements
TL;DR: Despite departures of the properties of the real lung from the characteristics of the acoustically equivalent structure, changes in the area-distance function computed by this technique provide reasonable estimates of the magnitude and serial distribution of actual changes in airway cross-sectional area.
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Is cytoskeletal tension a major determinant of cell deformability in adherent endothelial cells
Jacob Pourati,Andrew Maniotis,David S. Spiegel,Jonathan L. Schaffer,James P. Butler,Jeffrey J. Fredberg,Donald E. Ingber,D. Stamenovic,Ning Wang +8 more
TL;DR: The results suggest that the stretch-induced stiffening of adherent endothelial cells was primarily due to the direct mechanical changes in the forces distending the CSK but not to ATP- or Ca2+-dependent processes.
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Universal behavior of the osmotically compressed cell and its analogy to the colloidal glass transition
Enhua H. Zhou,Xavier Trepat,Chan Young Park,Guillaume Lenormand,Madavi Oliver,Srboljub M. Mijailovich,C. Corey Hardin,David A. Weitz,James P. Butler,Jeffrey J. Fredberg +9 more
TL;DR: This work provides a means to probe the physical nature of the cytoplasm under compression, and leads to results that are universal across cell type, which suggests that compression-induced weakening of the network is overwhelmed by crowding-induced stiffening of the Cy toplasm.
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Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces
Ramaswamy Krishnan,Darinka D. Klumpers,Chan Young Park,Kavitha Rajendran,Xavier Trepat,Jan van Bezu,Victor W.M. van Hinsbergh,Christopher V. Carman,Joseph D. Brain,Jeffrey J. Fredberg,James P. Butler,Geerten P. van Nieuw Amerongen +11 more
TL;DR: A central role of physical forces in EC gap formation is demonstrated and a novel physiological mechanism is highlighted, which in normal circumstances is compliant but during pathology becomes stiffer.
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Cell Elasticity Determines Macrophage Function
Naimish Patel,Medhavi Bole,Cheng Chen,Cheng Chen,C. Corey Hardin,Alvin T. Kho,Alvin T. Kho,Justin D. Mih,Linhong Deng,James P. Butler,Daniel J. Tschumperlin,Jeffrey J. Fredberg,Ramaswamy Krishnan,Henryk Koziel +13 more
TL;DR: An unanticipated role for cell elasticity is demonstrated as a common pathway by which mechanical and biologic factors determine macrophage function.