J
James P. Butler
Researcher at Harvard University
Publications - 324
Citations - 26460
James P. Butler is an academic researcher from Harvard University. The author has contributed to research in topics: Lung volumes & Obstructive sleep apnea. The author has an hindex of 74, co-authored 321 publications receiving 24090 citations. Previous affiliations of James P. Butler include Tohoku University & Brigham and Women's Hospital.
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Journal ArticleDOI
Fast and slow dynamics of the cytoskeleton
Linhong Deng,Linhong Deng,Xavier Trepat,James P. Butler,Emil Millet,Kathleen G. Morgan,Kathleen G. Morgan,David A. Weitz,Jeffrey J. Fredberg +8 more
TL;DR: These findings strongly suggest that at smaller timescales elasticity arises from entropic fluctuations of a semiflexible-filament network, whereas on longer timesCales slow (soft-glass-like) dynamics of a different origin prevail.
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3D Traction forces in cancer cell invasion.
TL;DR: It is found that invasive cells assumed an elongated spindle-like morphology as opposed to a more spherical shape of non-invasive cells, and the distribution of strain energy density around invasive cells followed patterns of increased complexity and anisotropy.
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Reinforcement versus Fluidization in Cytoskeletal Mechanoresponsiveness
Ramaswamy Krishnan,Chan Young Park,Yu-chun Lin,Jere Mead,Richard T. Jaspers,Xavier Trepat,Guillaume Lenormand,Dhananjay T. Tambe,Alexander V. Smolensky,Andrew H. Knoll,James P. Butler,Jeffrey J. Fredberg +11 more
TL;DR: It is shown here that in loading conditions expected in most physiological circumstances the localized reinforcement response fails to scale up to the level of homogeneous cell stretch; fluidization trumps reinforcement.
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Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells
Shaohua Hu,Jianxin Chen,Ben Fabry,Yasushi Numaguchi,Andrew Gouldstone,Donald E. Ingber,Jeffrey J. Fredberg,James P. Butler,Ning Wang +8 more
TL;DR: Data indicate that mechanical forces are transferred across discrete cytoskeletal elements over long distances through the cytoplasm in the living adherent cell.
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Friction in airway smooth muscle: mechanism, latch, and implications in asthma
Jeffrey J. Fredberg,Keith A. Jones,M. Nathan,Soufia Helioui Raboudi,Y. S. Prakash,Stephanie A. Shore,James P. Butler,Gary C. Sieck +7 more
TL;DR: Mechanical friction in airway smooth muscle is also governed by the rate of cross-bridge cycling, indicating that steady-state force maintenance (latch) is a low-friction contractile state and may account for the unique inability of asthmatic patients to reverse spontaneous airways obstruction with a deep inspiration.