J
Jamin W. Roh
Researcher at University of California, Davis
Publications - 11
Citations - 135
Jamin W. Roh is an academic researcher from University of California, Davis. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 3, co-authored 6 publications receiving 39 citations. Previous affiliations of Jamin W. Roh include University of California, Berkeley.
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Journal ArticleDOI
SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques.
Yashavanth Shaan Lakshmanappa,Sonny R. Elizaldi,Jamin W. Roh,Brian A. Schmidt,Timothy D. Carroll,Kourtney D. Weaver,Justin C Smith,Anil Verma,Jesse D. Deere,Joseph Dutra,Mars Stone,Sergej Franz,Rebecca L. Sammak,Katherine J. Olstad,J. Rachel Reader,J. Rachel Reader,Zhong-Min Ma,Nancy Nguyen,Jennifer Watanabe,Jodie Usachenko,Ramya Immareddy,Jo Ann L. Yee,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Dennis J. Hartigan-O'Connor,Dennis J. Hartigan-O'Connor,Stephen J. McSorley,John H. Morrison,John H. Morrison,Nam K. Tran,Graham Simmons,Michael P. Busch,Pamela A. Kozlowski,Koen K. A. Van Rompay,Koen K. A. Van Rompay,Christopher J. Miller,Christopher J. Miller,Smita S. Iyer,Smita S. Iyer +39 more
TL;DR: In this article, SARS-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion, resulted in transient accumulation of pro-inflammatory monocytes and proliferating Tfh cells with a Th1 profile in peripheral blood.
Journal ArticleDOI
SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19
Danielle Beckman,Alyssa C. Bonillas,Giovanne B. Diniz,Sean Ott,Jamin W. Roh,Sonny R. Elizaldi,Brian A. Schmidt,Rebecca L. Sammak,Koen K. A. Van Rompay,Smita S. Iyer,John Morris +10 more
TL;DR: In this article , the authors investigated whether SARS-CoV-2 reaches the brain and how viral neurotropism can be modulated by aging in a non-human primate model of COVID-19.
Journal ArticleDOI
Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques.
Koen K. A. Van Rompay,Koen K. A. Van Rompay,Katherine J. Olstad,Katherine J. Olstad,Rebecca L. Sammak,Joseph Dutra,Jennifer Watanabe,Jodie Usachenko,Ramya Immareddy,Anil Verma,Yashavanth Shaan Lakshmanappa,Brian A. Schmidt,Jamin W. Roh,Sonny R. Elizaldi,A. Mark Allen,Frauke Muecksch,Julio C. C. Lorenzi,Sarah Lockwood,Rachel E. Pollard,JoAnn L. Yee,Peter B. Nham,Amir Ardeshir,Jesse D. Deere,Jean L. Patterson,Que Dang,Theodora Hatziioannou,Paul D. Bieniasz,Paul D. Bieniasz,Smita S. Iyer,Smita S. Iyer,Dennis J. Hartigan-O'Connor,Dennis J. Hartigan-O'Connor,Michel C. Nussenzweig,Michel C. Nussenzweig,J. Rachel Reader,J. Rachel Reader +35 more
TL;DR: This article investigated the therapeutic efficacy of a combination of two potent monoclonal antibodies, C135-LS and C144-LS that carry half-life extension mutations, in the rhesus macaque model of COVID-19.
Posted ContentDOI
SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques
Sonny R. Elizaldi,Yashavanth Shaan Lakshmanappa,Jamin W. Roh,Brian A. Schmidt,Timothy D. Carroll,Kourtney D. Weaver,Justin C Smith,Jesse D. Deere,Joseph Dutra,Mars Stone,Rebecca L. Sammak,Katherine J. Olstad,J. Rachel Reader,Zhong-Min Ma,Nancy Nguyen,Jennifer Watanabe,Jodie Usachaenko,Ramya Immareddy,JoAnn L. Yee,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Dennis J. Hartigan-O'Connor,Stephen J. McSorley,John H. Morrison,Nam K Tran,Graham Simmons,Michael P. Busch,Pamela A. Kozlowski,Koen K. A. Van Rompay,Christopher J. Miller,Smita S. Iyer +31 more
TL;DR: It is reported that, following infection with SARS-CoV-2, adult rhesus macaques exhibited transient accumulation of activated, proliferating Tfh cells in their peripheral blood on a transitory basis and the data suggest that a vaccine promoting Th1-type T fh responses that target the S protein may lead to protective immunity.
Journal ArticleDOI
Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation.
Anil Verma,Chase E. Hawes,Yashavanth Shaan Lakshmanappa,Jamin W. Roh,Brian A. Schmidt,Joseph Dutra,William Louie,Hongwei Liu,Zhong-Min Ma,Jennifer Watanabe,Jodie Usachenko,Ramya Immareddy,Rebecca L. Sammak,Rachel E. Pollard,J. Rachel Reader,J. Rachel Reader,Katherine J. Olstad,Katherine J. Olstad,Lark L. Coffey,Pamela A. Kozlowski,Dennis J. Hartigan-O'Connor,Dennis J. Hartigan-O'Connor,Michel C. Nussenzweig,Koen K. A. Van Rompay,Koen K. A. Van Rompay,John H. Morrison,John H. Morrison,Smita S. Iyer,Smita S. Iyer +28 more
TL;DR: In this article, anti-viral monoclonal antibody (mAb) treatments may provide immediate but short-term immunity from coronavirus disease 2019 (COVID-19) in high-risk populations, such as people with diabetes and the elderly; however, data on their efficacy in these populations are limited.