J
Jan Muschiol
Researcher at Technical University of Denmark
Publications - 21
Citations - 1098
Jan Muschiol is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Active site & Enzyme. The author has an hindex of 12, co-authored 20 publications receiving 759 citations. Previous affiliations of Jan Muschiol include University of Greifswald.
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Journal ArticleDOI
Cascade catalysis – strategies and challenges en route to preparative synthetic biology
Jan Muschiol,Christin Peters,Nikolin Oberleitner,Marko D. Mihovilovic,Uwe T. Bornscheuer,Florian Rudroff +5 more
TL;DR: This review will focus on major contributions in the field of cascade reactions over the last three years.
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An Enzyme Cascade Synthesis of ε-Caprolactone and its Oligomers
Sandy Schmidt,Christian Scherkus,Jan Muschiol,Ulf Menyes,Till Winkler,Werner Hummel,Harald Gröger,Andreas Liese,Hans Georg Herz,Uwe T. Bornscheuer +9 more
TL;DR: Key to success was a subsequent direct ring-opening oligomerization of in situ formed ε-CL in the aqueous phase by using lipase A from Candida antarctica, thus efficiently solving the product inhibition problem and leading to the formation of oligo-ε-CL.
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Phenolic cross-links: building and de-constructing the plant cell wall
Ewelina Mnich,Nanna Bjarnholt,Aymerick Eudes,Aymerick Eudes,Jesper Harholt,Claire Holland,Bodil Jørgensen,Flemming H. Larsen,Ming Liu,Renil Manat,Anne S. Meyer,Jørn Dalgaard Mikkelsen,Mohammed Saddik Motawia,Jan Muschiol,Birger Lindberg Møller,Svenning Rune Møller,Alixander Perzon,Bent O. Petersen,Jonas Laukkonen Ravn,Peter Ulvskov +19 more
TL;DR: This review summarizes current knowledge on the intra- and extracellular acylation of polysaccharides, and inter- and intra-molecular cross-linking of different constituents.
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A structural-chemical explanation of fungal laccase activity
TL;DR: The results suggest that Km is not just a binding constant but also contains features of the enzymatic activity, and advance the ability to model laccase activity and lend promise to future rational optimization of laccases toward phenolic substrates.
Journal ArticleDOI
An Enzymatic Toolbox for Cascade Reactions: A Showcase for an In Vivo Redox Sequence in Asymmetric Synthesis
Nikolin Oberleitner,Christin Peters,Jan Muschiol,Maria Kadow,Stefan Saß,Thomas Bayer,Patricia Schaaf,Naseem Iqbal,Florian Rudroff,Marko D. Mihovilovic,Uwe T. Bornscheuer +10 more
TL;DR: The prime novelty and major aim of the present study was to combine the efficiency of biosynthetic redox pathways, the modularity of synthesis by simple functional group transformations, and the substrate promiscuity of enzymes.