Janis Racevskis

TL;DR: Transblot analysis of HepG2 cell lysates indicated that the progressive loss in the steady-state level of asialoglycoprotein receptor (ASGR) when cells were maintained in medium supplemented with dialyzed fetal bovine serum was reversed by the addition of cell-permeant 8-bromo-cGMP.

TL;DR: Poly(A+) RNA analysis of the normal liver and HepG2 cells by complementary RNA hybridization and ribonuclease protection corroborated the observations made during the screening of complementary DNA libraries regarding the abundance of the various messages.

TL;DR: The addition of dasatinib to chemotherapy followed by an alloSCT in the eligible patients would lead to a significant improvement in relapse-free survival and the potential value of detection of minimal residual disease (MRD) using quantitative PCR for BCR-ABL fusion transcripts at defined intervals is examined.

TL;DR: Delta TL was found to be the most powerful predictor of overall survival when compared with well-established risk factors for poor outcomes in APL and shorter telomeres at diagnosis were significantly associated with high-risk disease.

TL;DR: DNA microarrays were used to identify gene expression profiles and molecular interaction networks related to BCR/ABL status and clinical outcome in a set of 54 adult ALL specimens from the MRC UKALL XII/ECOG E2993 intergroup study and constructed an indirect two-step labeling protocol based on signal amplification by use of dendrimer technology.