J
Jason E. Gestwicki
Researcher at University of California, San Francisco
Publications - 280
Citations - 27231
Jason E. Gestwicki is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Chaperone (protein) & Heat shock protein. The author has an hindex of 69, co-authored 250 publications receiving 23446 citations. Previous affiliations of Jason E. Gestwicki include Research Triangle Park & Stanford University.
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Journal ArticleDOI
The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT).
Cory M. Nadel,Aye C. Thwin,Matthew D. Callahan,Kang Hyun Lee,Emily Connelly,Charles S. Craik,Daniel R. Southworth,Jason E. Gestwicki +7 more
TL;DR: In this article , a panel of chaperones containing tetratricopeptide repeat (TPR) domains was screened to identify those that might selectively interact with phosphorylated tau.
Posted ContentDOI
Managing the Spatial Covariance of Genetic Diversity in Niemann-Pick C1 Through Modulation of the Hsp70 Chaperone System
TL;DR: Together, these studies suggest that targeting the cytosolic Hsp70 system to adjust the SCV tolerance of the proteostasis network can improve recognition of the plasticity of the NPC1 fold found in the disease population for trafficking to the LE/Ly compartments.
Journal ArticleDOI
Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels.
Hao Shao,Xiaokai Li,Shigenari Hayashi,Jeanette L. Bertron,Daniel M. C. Schwarz,Benjamin C. Tang,Jason E. Gestwicki +6 more
TL;DR: In this article, the authors designed and synthesized seventeen YM-08 derivatives by systematically introducing halogen atoms to the benzothiazole ring and shifting the position of the heteroatom in a distal pyridine.