J
Jason E. Gestwicki
Researcher at University of California, San Francisco
Publications - 280
Citations - 27231
Jason E. Gestwicki is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Chaperone (protein) & Heat shock protein. The author has an hindex of 69, co-authored 250 publications receiving 23446 citations. Previous affiliations of Jason E. Gestwicki include Research Triangle Park & Stanford University.
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Journal ArticleDOI
Direct and Propagated Effects of Small Molecules on Protein–Protein Interaction Networks
TL;DR: In this article, the authors highlight developments that have opened the door to potent chemical modulators for protein-protein interactions (PPIs) and discuss how interfering with one PPI can propagate changes through the broader web of interactions.
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The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex.
Matthew C. Smith,K. Matthew Scaglione,Victoria A. Assimon,Srikanth Patury,Andrea D. Thompson,Chad A. Dickey,Daniel R. Southworth,Henry L. Paulson,Jason E. Gestwicki,Jason E. Gestwicki,Erik R. P. Zuiderweg +10 more
TL;DR: It is suggested that a dynamic C-terminal region of Hsc70 provides for flexibility between CHIP and the chaperone, allowing the ligase to "search" a large space and engage in productive interactions with a wide range of clients.
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Visualization and functional analysis of the oligomeric states of Escherichia coli heat shock protein 70 (Hsp70/DnaK)
TL;DR: DnaK oligomers are composed of ordered multimers that are functionally distinct from monomeric DnaK, suggesting that oligomerization of DNAK might be an important step in chaperone cycling.
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KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice
Euan S. Polson,Verena Kuchler,Christopher Abbosh,Edith M. Ross,Ryan K. Mathew,Ryan K. Mathew,Hester A. Beard,Barbara da Silva,Andrew N Holding,Stephane Ballereau,Eulashini Chuntharpursat-Bon,Jennifer Williams,Hollie B. S. Griffiths,Hao Shao,Anjana Patel,Adam J. Davies,Alastair Droop,Paul Chumas,Susan C Short,Mihaela Lorger,Jason E. Gestwicki,Lee D. Roberts,Robin S. Bon,Simon J. Allison,Shoutian Zhu,Florian Markowetz,Heiko Wurdak +26 more
TL;DR: It is shown that the synthetic small-molecule KHS101 promoted tumor cell death in diverse GBM cell models, independent of their tumor subtype, and without affecting the viability of noncancerous brain cell lines, and suggest that targeting of HSPD1-dependent metabolic pathways might be an effective strategy for treating GBM.
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Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy.
Kateryna Morozova,Cristina C. Clement,Susmita Kaushik,Barbara Stiller,Esperanza Arias,Atta Ahmad,Jennifer N. Rauch,Victor Chatterjee,Chiara Melis,Brian Scharf,Jason E. Gestwicki,Ana Maria Cuervo,Erik R. P. Zuiderweg,Laura Santambrogio +13 more
TL;DR: By combining plasmon resonance, NMR spectroscopy, and amino acid mutagenesis, the C terminus of the hsc-70 LID domain is mapped as the structural interface interacting with endosomal PS, which elucidates the mechanism of hSc-70 PS/membrane interaction for cytosolic cargo internalization into endosomes.