J
Jason E. Gestwicki
Researcher at University of California, San Francisco
Publications - 280
Citations - 27231
Jason E. Gestwicki is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Chaperone (protein) & Heat shock protein. The author has an hindex of 69, co-authored 250 publications receiving 23446 citations. Previous affiliations of Jason E. Gestwicki include Research Triangle Park & Stanford University.
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Journal ArticleDOI
Contact Angle Goniometry as a Tool for Surface Tension Measurements of Solids, Using Zisman Plot Method A Physical Chemistry Experiment
TL;DR: In this paper, a physical chemistry experiment for measurement of surface tension of solids is described, which includes a detailed experimental procedure for surface tension measurements using contact angle goniometry.
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Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks
Melanie Meister-Broekema,Rebecca Freilich,Chandhuru Jagadeesan,Chandhuru Jagadeesan,Jennifer N. Rauch,Rocio Bengoechea,William W. Motley,E. F. Elsiena Kuiper,Melania Minoia,Gabriel Vasata Furtado,Gabriel Vasata Furtado,Maria A.W.H. van Waarde,Shawn J. Bird,Adriana P. Rebelo,Stephan Züchner,Peter Pytel,Steven S. Scherer,Federica Francesca Morelli,Serena Carra,Serena Carra,Conrad C. Weihl,Steven Bergink,Jason E. Gestwicki,Harm H. Kampinga +23 more
TL;DR: Here the authors show that several myofibrillar myopathy causing BAG3 mutations are not impaired in Hsp70 binding, but rather impair the ADP-ATP exchange step of the HSp70 cycle, causing the aggregation of B AG3, HSP70 and Hsp 70 clients and leading to a collapse of protein homeostasis.
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Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.
Xu Chen,Yaqiao Li,Chao Wang,Yinyan Tang,Sue-Ann Mok,Richard M. Tsai,Julio C. Rojas,Anna Karydas,Bruce L. Miller,Adam L. Boxer,Jason E. Gestwicki,Michelle R. Arkin,Ana Maria Cuervo,Li Gan,Li Gan +14 more
TL;DR: It is reported that p300/CBP, a lysine acetyltransferase aberrantly activated in tauopathies, causes impairment in ALP, leading to excess tau secretion, contributing to enhanced spreading of tau.
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Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies
TL;DR: One potential way to treat tauopathies might be to either accelerate interactions of abnormal tau with these quality control factors or tip the balance of triage towards tau degradation.
Journal ArticleDOI
Inhibitors and chemical probes for molecular chaperone networks.
Jason E. Gestwicki,Hao Shao +1 more
TL;DR: Progress toward producing inhibitors for a broader set of targets is discussed and some of the challenges ahead are pointed out.