J
Jason E. Gestwicki
Researcher at University of California, San Francisco
Publications - 280
Citations - 27231
Jason E. Gestwicki is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Chaperone (protein) & Heat shock protein. The author has an hindex of 69, co-authored 250 publications receiving 23446 citations. Previous affiliations of Jason E. Gestwicki include Research Triangle Park & Stanford University.
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Two‐ and Three‐Hybrid Systems
Jason E. Gestwicki,Anuj Kumar +1 more
TL;DR: This review discusses the classic yeast two-hybrid method (and its derivatives) and how this method continues to provide insight into the number of protein–protein partnerships in a cell, and emerging ways of minimizing the impact of these limitations using microarrays and mass spectrometry.
Posted ContentDOI
A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway
Suzanne Elsasser,Lisa P. Elia,Richard I. Morimoto,Daniel Finley,Beatrice Costa,Zachary Tokuno,Shijie Wang,Rajshri G. Iyer,Bianca Barth,Eric Mockler,Steven Finkbeiner,Jason E. Gestwicki,Reese A.K. Richardson,Thomas Stoeger,Ee Phie Tan,Q Xiao,Christian Cole,Lynée A. Massey,Dan Garza,Evan T. Powers,Jeffery W. Kelly,T. Kelly Rainbolt,Ching Chieh Chou,Vincent B. Masto,Judith Frydman,Ralph A. Nixon +25 more
TL;DR: The autophagy-lysosome pathway is one of the two major protein degradation systems in human cells as mentioned in this paper , and a curated list of 838 unique high-confidence components of the pathway is presented in this paper.
Journal ArticleDOI
Molecular recognition of pathological tau fibril conformations
TL;DR: This paper showed that fibrils adopt unique tauopathy-dependent conformations that differ from those of heparin-induced recombinant tau-fibrils in vitro, and an understanding of the cellular factors driving conformation-specific fibrillization is hampered by a lack of tools for determining fibril conformation.
Journal ArticleDOI
Abstract 4606: Heat shock proteins in immunosuppressive tumor microenvironment
Fulya Koksalar Alkan,Justin E. Wilson,Elayne M Benson,Tulshi Patel,Ahmed Chadli,Jason E. Gestwicki,Hasan Korkaya +6 more
TL;DR: Alkan et al. as discussed by the authors showed that upregulation of A20 in TNBC subtype in response to TNFα protects these cells from cytotoxic cell death by upregulating HSP70 protein and maintaining EMT/CSC phenotype.