J
Jason E. Gestwicki
Researcher at University of California, San Francisco
Publications - 280
Citations - 27231
Jason E. Gestwicki is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Chaperone (protein) & Heat shock protein. The author has an hindex of 69, co-authored 250 publications receiving 23446 citations. Previous affiliations of Jason E. Gestwicki include Research Triangle Park & Stanford University.
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Journal ArticleDOI
Validation of the Hsp70–Bag3 Protein–Protein Interaction as a Potential Therapeutic Target in Cancer
Xiaokai Li,Teresa A. Colvin,Jennifer N. Rauch,Diego Acosta-Alvear,Martin Kampmann,Bryan M. Dunyak,Byron Hann,Blake T. Aftab,Megan Murnane,Min Cho,Peter Walter,Jonathan S. Weissman,Michael Y. Sherman,Jason E. Gestwicki +13 more
TL;DR: JG-98, an allosteric inhibitor of this PPI, indeed has antiproliferative activity across cancer cell lines from multiple origins and suggested that the Hsp70–Bag3 interaction may be a promising, new target for anticancer therapy.
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Synthetische multivalente Liganden als Sonden fÜr die Signaltransduktion
TL;DR: In this paper, synthetische Verbindungen konnen dabei helfen, die Rolle der Rezeptorassoziationen bei der Signaltransduktion zu ermitteln.
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Imbalance of Hsp70 family variants fosters tau accumulation
Umesh K. Jinwal,Elias Akoury,Jose F. Abisambra,John C. O'Leary,Andrea D. Thompson,Laura J. Blair,Ying Jin,Justin Bacon,Bryce A. Nordhues,Matthew Cockman,Juan Zhang,Pengfei Li,Bo Zhang,Sergiy Borysov,Vladimir N. Uversky,Jacek Biernat,Eckhard Mandelkow,Jason E. Gestwicki,Markus Zweckstetter,Chad A. Dickey +19 more
TL;DR: It is demonstrated that highly homologous variants in the Hsp70 family can have opposing effects on tau clearance kinetics, and efforts to promote Hsp72 expression and inhibit Hsc70 could be therapeutically relevant for tauopathies.
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The remarkable multivalency of the Hsp70 chaperones
TL;DR: What is known about the interaction between the chaperones and partners of Hsp70s, and HSPA8 in particular, is reviewed, with a strong slant toward structural biology.
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Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels
Yoshinari Miyata,Xiaokai Li,Hsiu Fang Lee,Umesh K. Jinwal,Sharan R. Srinivasan,Sandlin P. Seguin,Zapporah T. Young,Jeffrey L. Brodsky,Chad A. Dickey,Duxin Sun,Jason E. Gestwicki +10 more
TL;DR: YM-08 is a promising scaffold for the development of Hsp70 inhibitors suitable for use in the central nervous system (CNS), and replacing the cationic pyridinium moiety in MKT-077 with a neutral pyridine might improve its clogP and enhance its BBB penetrance.