J
Jason E. Gestwicki
Researcher at University of California, San Francisco
Publications - 280
Citations - 27231
Jason E. Gestwicki is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Chaperone (protein) & Heat shock protein. The author has an hindex of 69, co-authored 250 publications receiving 23446 citations. Previous affiliations of Jason E. Gestwicki include Research Triangle Park & Stanford University.
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Journal ArticleDOI
Conditional nuclear import and export of yeast proteins using a chemical inducer of dimerization.
TL;DR: Testing the ability of a technology to control protein position in budding yeast using a chemical inducer of dimerization to direct the nucleocytoplasmic transport of 16 representative kinases and transcription factors found that 12 targets are susceptible to re-positioning, suggesting that this method might be applicable to a range of targets.
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Clarifying allosteric control of flap conformations in the 1TW7 crystal structure of HIV-1 protease.
TL;DR: Additional simulations are conducted, supplemented with experimental testing, to further probe the possibility of 1TW7 providing an example of allosteric control of the flap region and show that the contacts are unstable and do not restrict the conformational sampling of the flaps.
Posted ContentDOI
PIKfyve inhibition blocks endolysosomal escape of α-synuclein fibrils and spread of α-synuclein aggregation
Stephanie K. See,Merissa Chen,Sophie Bax,Ruilin Tian,Amanda L. Woerman,Eric Tse,Isabel E. Johnson,Carlos Nowotny,Elise N Munoz,Janine Sengstack,Daniel R. Southworth,Jason E. Gestwicki,Manuel D. Leonetti,Martin Kampmann +13 more
TL;DR: In this article, the authors performed a genome-wide CRISPR interference screen in a human cell-based model to discover therapeutic strategies reducing the spread of α-synuclein aggregation.
Journal ArticleDOI
Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate
Daniel Carneiro Carrettiero,Maria Carolina de Almeida,Andrew P. Longhini,Jennifer N. Rauch,Dasol Han,Xuemei Zhang,Saeed Najafi,Jason E. Gestwicki,Kenneth S. Kosik +8 more
TL;DR: The formation of membraneless organelles can be a proteotoxic stress control mechanism that locally condenses a set of components capable of mediating protein degradation decisions as discussed by the authors .
Journal ArticleDOI
Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules
Mackenzie D. Martin,Jeremy D. Baker,Amirthaa Suntharalingam,Bryce A. Nordhues,Lindsey B. Shelton,Dali Zheng,Jonathan J. Sabbagh,Timothy A.J. Haystead,Jason E. Gestwicki,Chad A. Dickey +9 more
TL;DR: Investigation of the anti-tau efficacy of additional scaffolds with Hsp70 inhibitory activity found that compounds possessing both activities were the most effective at promoting tau clearance.