J
Jason E. Gestwicki
Researcher at University of California, San Francisco
Publications - 280
Citations - 27231
Jason E. Gestwicki is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Chaperone (protein) & Heat shock protein. The author has an hindex of 69, co-authored 250 publications receiving 23446 citations. Previous affiliations of Jason E. Gestwicki include Research Triangle Park & Stanford University.
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Journal ArticleDOI
Individualized management of genetic diversity in Niemann-Pick C1 through modulation of the Hsp70 chaperone system.
Chao Wang,Samantha M. Scott,Shuhong Sun,Pei Zhao,Darren M. Hutt,Hao Shao,Jason E. Gestwicki,William E. Balch +7 more
TL;DR: It is proposed that targeting the cytosolic Hsp70 system by allosteric regulation of its chaperone/co-chaperone based client relationships can be used to adjust the SCV tolerance of proteostasis buffering capacity to provide an approach to mitigate systemic and neurological disease in the NPC1 population.
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Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction
TL;DR: A modified synthetic route with significantly improved overall yield and modifications of the hemiaminal significantly increased chemical stability is reported, anticipating that this synthetic route will improve access to biologically active 15-DSG derivatives.
Journal ArticleDOI
Deconvolution Method for Specific and Nonspecific Binding of Ligand to Multiprotein Complex by Native Mass Spectrometry
Shenheng Guan,Michael J. Trnka,David A. Bushnell,Philip Robinson,Jason E. Gestwicki,Alma L. Burlingame +5 more
TL;DR: A deconvolution model that consists of two levels of data reduction found that a power-law distribution described nonspecific binding of α-amanitin to yeast RNA polymerase II and treating the concentration of the multiprotein complex as a fitting parameter reduced the impact of inaccuracies in this experimental measurement on the apparent association constants.
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Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy
Rocio Bengoechea,Andrew R. Findlay,Ankan K. Bhadra,Hao Shao,Kevin C. Stein,Sara K. Pittman,Jil A. Wright Daw,Jason E. Gestwicki,Heather L. True,Conrad C. Weihl +9 more
TL;DR: Using yeast, cell culture, and mouse models of LGMDD1, it is found that the toxicity associated with disease-associated DNAJB6 required its interaction with HSP70, and that abrogating this interaction genetically or with small molecules was protective.
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A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions.
Silvia Rinaldi,Victoria A. Assimon,Zapporah T. Young,Giulia Morra,Hao Shao,Isabelle R. Taylor,Jason E. Gestwicki,Giorgio Colombo +7 more
TL;DR: An integrated computational and experimental approach is used to probe the molecular mechanism of an allosteric inhibitor of heat shock protein 70 and synthesizes an analog of MKT-077 that would better prevent motions of loop222 and confirmed that it had improved antiproliferative activity in breast cancer cells.