J
Jason E. Gestwicki
Researcher at University of California, San Francisco
Publications - 280
Citations - 27231
Jason E. Gestwicki is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Chaperone (protein) & Heat shock protein. The author has an hindex of 69, co-authored 250 publications receiving 23446 citations. Previous affiliations of Jason E. Gestwicki include Research Triangle Park & Stanford University.
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From Fuzzy to Function: The New Frontier of Protein–Protein Interactions
TL;DR: Conformationally heterogenous or "fuzzy" proteins have often been described as lacking specificity in binding and in function, but emerging data illustrates that conformational heterogeneity enables context-specific function to emerge in response to changing cellular conditions.
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Identification of dihydropyridines that reduce cellular tau levels
TL;DR: A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease.
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The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein
Isabelle R. Taylor,Atta Ahmad,Taia Wu,Bryce A. Nordhues,Anup Bhullar,Jason E. Gestwicki,Erik R. P. Zuiderweg +6 more
TL;DR: The interaction between the human Hsp70 isoform heat shock cognate 71-kDa protein (Hsc70 or HSPA8) and peptides derived from the microtubule-associated protein Tau, which is linked to Alzheimer's disease is reported.
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Chemical probes that selectively recognize the earliest Aβ oligomers in complex mixtures.
TL;DR: Bivalent versions of the known Aβ ligand, the pentapeptide KLVFF, are generated that recognized primarily Aβ trimers and tetramers, with little binding to either monomer or higher order structures.
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HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C
Amelia A. Glazier,Neha Hafeez,Dattatreya Mellacheruvu,Venkatesha Basrur,Alexey I. Nesvizhskii,Lap Man Lee,Hao Shao,Vi T. Tang,Jaime Yob,Jason E. Gestwicki,Adam S. Helms,Sharlene M. Day +11 more
TL;DR: In an unbiased coimmunoprecipitation/mass spectrometry screen, HSP70-family chaperones were identified as interactors of both WT and mutant MYBPC3, and it is suggested that the HSC70 chaperone system plays a major role in regulating MYB PC3 protein turnover.